Is X 115 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use X 115? Is X 115 safe for nursing mother and child? Does X 115 extracts into breast milk? Does X 115 has any long term or short term side effects on infants? Can X 115 influence milk supply or can X 115 decrease milk supply in lactating mothers?

One case of nausea, vomiting and irritability has been described. However, X 115 has been used as treatment of apnea on premature babies. It can enhance milk production by stimulating prolactin release.

An expert panel considers use of X 115 to be acceptable during breastfeeding.[1] Maternal X 115 use may occasionally cause stimulation and irritability and fretful sleep in infants. Newborn and especially preterm infants are most likely to be affected because of their slow elimination and low serum protein binding of X 115. There is no need to avoid X 115 products; however, keep maternal serum concentrations in the lower part of the therapeutic range and monitor the infant for signs of X 115 side effects. Infant serum X 115 concentrations can help to determine if signs of agitation are due to X 115. Avoiding breastfeeding for an 2 hours after intravenous or 4 hours after an immediate-release oral X 115 product can decrease the dose received by the breastfed infant. When X 115 is given as an oral sustained-release product, timing of nursing with respect to the dose is of little or no benefit.

Irritability and fretful sleeping occurred in a 3-day-old breastfed infant on days of maternal aminophylline intake of 200 mg every 6 hours. These effects ceased with discontinuation and recurred on rechallenge over the next 9 months. These effects were probably caused by X 115 in breastmilk. Another five infants reported in this paper showed no adverse reactions after maternal X 115 ingestion.[3] Accumulation of X 115 in infant serum appears most likely in neonates and premature infants because they eliminate X 115 slowly.[2][5]