Question

I am a breastfeeding mother and i want to know if it is safe to use Anthrax Immune Globulin Intravenous (Human)? Is Anthrax Immune Globulin Intravenous (Human) safe for nursing mother and child? Does Anthrax Immune Globulin Intravenous (Human) extracts into breast milk? Does Anthrax Immune Globulin Intravenous (Human) has any long term or short term side effects on infants? Can Anthrax Immune Globulin Intravenous (Human) influence milk supply or can Anthrax Immune Globulin Intravenous (Human) decrease milk supply in lactating mothers?

Answer by DrLact: About Anthrax Immune Globulin Intravenous (Human) usage in lactation

Anthrax immune globulin is aN immune globulin (IgG) rich in IgG antibodies against toxins. IgG is a normal component of breastmilk. No special precautions are required. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[1][2] Higher temperatures of 72 and 85 degrees C appear to cause greater loss, but further lyophylization does not cause marked additional loss.[3] A flash heating pasteurization reduced the concentration of endogenous immunoglobulin G by 33%.[4] A continuous flow, high-temperature short-time (HTST) pasteurizer at temperatures ranging from 71 to 74 degrees C retained from about 38 to 79% of IgG activity depending on the temperature and exposure time.[5] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Immunoreactivity against ovalbumin decreased by 4 to 18% and immunoreactivity against tetanus toxoid decreased by 8 to 20%. Specific IgG subclasses decreased by different amounts, with IgG4 retaining all of its activity and IgG1 and 2 decreasing by about 40 to 50%.[6]
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