Is AI3-50216 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use AI3-50216? Is AI3-50216 safe for nursing mother and child? Does AI3-50216 extracts into breast milk? Does AI3-50216 has any long term or short term side effects on infants? Can AI3-50216 influence milk supply or can AI3-50216 decrease milk supply in lactating mothers?
AI3-50216 lactation summary
- DrLact safety Score for AI3-50216 is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of AI3-50216 is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that AI3-50216 does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of AI3-50216 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About AI3-50216 usage in lactation
One case of nausea, vomiting and irritability has been described. However, AI3-50216 has been used as treatment of apnea on premature babies. It can enhance milk production by stimulating prolactin release.
Answer by DrLact: About AI3-50216 usage in lactation
An expert panel considers use of AI3-50216 to be acceptable during breastfeeding.[1] Maternal AI3-50216 use may occasionally cause stimulation and irritability and fretful sleep in infants. Newborn and especially preterm infants are most likely to be affected because of their slow elimination and low serum protein binding of AI3-50216. There is no need to avoid AI3-50216 products; however, keep maternal serum concentrations in the lower part of the therapeutic range and monitor the infant for signs of AI3-50216 side effects. Infant serum AI3-50216 concentrations can help to determine if signs of agitation are due to AI3-50216. Avoiding breastfeeding for an 2 hours after intravenous or 4 hours after an immediate-release oral AI3-50216 product can decrease the dose received by the breastfed infant. When AI3-50216 is given as an oral sustained-release product, timing of nursing with respect to the dose is of little or no benefit.
AI3-50216 Side Effects in Breastfeeding
Irritability and fretful sleeping occurred in a 3-day-old breastfed infant on days of maternal aminophylline intake of 200 mg every 6 hours. These effects ceased with discontinuation and recurred on rechallenge over the next 9 months. These effects were probably caused by AI3-50216 in breastmilk. Another five infants reported in this paper showed no adverse reactions after maternal AI3-50216 ingestion.[3] Accumulation of AI3-50216 in infant serum appears most likely in neonates and premature infants because they eliminate AI3-50216 slowly.[2][5]
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