Is 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione? Is 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione safe for nursing mother and child? Does 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione extracts into breast milk? Does 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione has any long term or short term side effects on infants? Can 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione influence milk supply or can 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione decrease milk supply in lactating mothers?

One case of nausea, vomiting and irritability has been described. However, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione has been used as treatment of apnea on premature babies. It can enhance milk production by stimulating prolactin release.

An expert panel considers use of 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione to be acceptable during breastfeeding.[1] Maternal 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione use may occasionally cause stimulation and irritability and fretful sleep in infants. Newborn and especially preterm infants are most likely to be affected because of their slow elimination and low serum protein binding of 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione. There is no need to avoid 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione products; however, keep maternal serum concentrations in the lower part of the therapeutic range and monitor the infant for signs of 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione side effects. Infant serum 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione concentrations can help to determine if signs of agitation are due to 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione. Avoiding breastfeeding for an 2 hours after intravenous or 4 hours after an immediate-release oral 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione product can decrease the dose received by the breastfed infant. When 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione is given as an oral sustained-release product, timing of nursing with respect to the dose is of little or no benefit.

Irritability and fretful sleeping occurred in a 3-day-old breastfed infant on days of maternal aminophylline intake of 200 mg every 6 hours. These effects ceased with discontinuation and recurred on rechallenge over the next 9 months. These effects were probably caused by 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione in breastmilk. Another five infants reported in this paper showed no adverse reactions after maternal 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione ingestion.[3] Accumulation of 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione in infant serum appears most likely in neonates and premature infants because they eliminate 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione slowly.[2][5]