Is Doraphyllin Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Doraphyllin? Is Doraphyllin safe for nursing mother and child? Does Doraphyllin extracts into breast milk? Does Doraphyllin has any long term or short term side effects on infants? Can Doraphyllin influence milk supply or can Doraphyllin decrease milk supply in lactating mothers?
Doraphyllin lactation summary
- DrLact safety Score for Doraphyllin is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of Doraphyllin is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that Doraphyllin does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of Doraphyllin safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Doraphyllin usage in lactation
One case of nausea, vomiting and irritability has been described. However, Doraphyllin has been used as treatment of apnea on premature babies. It can enhance milk production by stimulating prolactin release.
Answer by DrLact: About Doraphyllin usage in lactation
An expert panel considers use of Doraphyllin to be acceptable during breastfeeding.[1] Maternal Doraphyllin use may occasionally cause stimulation and irritability and fretful sleep in infants. Newborn and especially preterm infants are most likely to be affected because of their slow elimination and low serum protein binding of Doraphyllin. There is no need to avoid Doraphyllin products; however, keep maternal serum concentrations in the lower part of the therapeutic range and monitor the infant for signs of Doraphyllin side effects. Infant serum Doraphyllin concentrations can help to determine if signs of agitation are due to Doraphyllin. Avoiding breastfeeding for an 2 hours after intravenous or 4 hours after an immediate-release oral Doraphyllin product can decrease the dose received by the breastfed infant. When Doraphyllin is given as an oral sustained-release product, timing of nursing with respect to the dose is of little or no benefit.
Doraphyllin Side Effects in Breastfeeding
Irritability and fretful sleeping occurred in a 3-day-old breastfed infant on days of maternal aminophylline intake of 200 mg every 6 hours. These effects ceased with discontinuation and recurred on rechallenge over the next 9 months. These effects were probably caused by Doraphyllin in breastmilk. Another five infants reported in this paper showed no adverse reactions after maternal Doraphyllin ingestion.[3] Accumulation of Doraphyllin in infant serum appears most likely in neonates and premature infants because they eliminate Doraphyllin slowly.[2][5]
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