Is HSDB 3399 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use HSDB 3399? Is HSDB 3399 safe for nursing mother and child? Does HSDB 3399 extracts into breast milk? Does HSDB 3399 has any long term or short term side effects on infants? Can HSDB 3399 influence milk supply or can HSDB 3399 decrease milk supply in lactating mothers?

One case of nausea, vomiting and irritability has been described. However, HSDB 3399 has been used as treatment of apnea on premature babies. It can enhance milk production by stimulating prolactin release.

An expert panel considers use of HSDB 3399 to be acceptable during breastfeeding.[1] Maternal HSDB 3399 use may occasionally cause stimulation and irritability and fretful sleep in infants. Newborn and especially preterm infants are most likely to be affected because of their slow elimination and low serum protein binding of HSDB 3399. There is no need to avoid HSDB 3399 products; however, keep maternal serum concentrations in the lower part of the therapeutic range and monitor the infant for signs of HSDB 3399 side effects. Infant serum HSDB 3399 concentrations can help to determine if signs of agitation are due to HSDB 3399. Avoiding breastfeeding for an 2 hours after intravenous or 4 hours after an immediate-release oral HSDB 3399 product can decrease the dose received by the breastfed infant. When HSDB 3399 is given as an oral sustained-release product, timing of nursing with respect to the dose is of little or no benefit.

Irritability and fretful sleeping occurred in a 3-day-old breastfed infant on days of maternal aminophylline intake of 200 mg every 6 hours. These effects ceased with discontinuation and recurred on rechallenge over the next 9 months. These effects were probably caused by HSDB 3399 in breastmilk. Another five infants reported in this paper showed no adverse reactions after maternal HSDB 3399 ingestion.[3] Accumulation of HSDB 3399 in infant serum appears most likely in neonates and premature infants because they eliminate HSDB 3399 slowly.[2][5]