Is HSDB 3399 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use HSDB 3399? Is HSDB 3399 safe for nursing mother and child? Does HSDB 3399 extracts into breast milk? Does HSDB 3399 has any long term or short term side effects on infants? Can HSDB 3399 influence milk supply or can HSDB 3399 decrease milk supply in lactating mothers?
HSDB 3399 lactation summary
- DrLact safety Score for HSDB 3399 is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of HSDB 3399 is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that HSDB 3399 does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of HSDB 3399 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About HSDB 3399 usage in lactation
One case of nausea, vomiting and irritability has been described. However, HSDB 3399 has been used as treatment of apnea on premature babies. It can enhance milk production by stimulating prolactin release.
Answer by DrLact: About HSDB 3399 usage in lactation
An expert panel considers use of HSDB 3399 to be acceptable during breastfeeding.[1] Maternal HSDB 3399 use may occasionally cause stimulation and irritability and fretful sleep in infants. Newborn and especially preterm infants are most likely to be affected because of their slow elimination and low serum protein binding of HSDB 3399. There is no need to avoid HSDB 3399 products; however, keep maternal serum concentrations in the lower part of the therapeutic range and monitor the infant for signs of HSDB 3399 side effects. Infant serum HSDB 3399 concentrations can help to determine if signs of agitation are due to HSDB 3399. Avoiding breastfeeding for an 2 hours after intravenous or 4 hours after an immediate-release oral HSDB 3399 product can decrease the dose received by the breastfed infant. When HSDB 3399 is given as an oral sustained-release product, timing of nursing with respect to the dose is of little or no benefit.
HSDB 3399 Side Effects in Breastfeeding
Irritability and fretful sleeping occurred in a 3-day-old breastfed infant on days of maternal aminophylline intake of 200 mg every 6 hours. These effects ceased with discontinuation and recurred on rechallenge over the next 9 months. These effects were probably caused by HSDB 3399 in breastmilk. Another five infants reported in this paper showed no adverse reactions after maternal HSDB 3399 ingestion.[3] Accumulation of HSDB 3399 in infant serum appears most likely in neonates and premature infants because they eliminate HSDB 3399 slowly.[2][5]
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