Is Medaphyllin Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Medaphyllin? Is Medaphyllin safe for nursing mother and child? Does Medaphyllin extracts into breast milk? Does Medaphyllin has any long term or short term side effects on infants? Can Medaphyllin influence milk supply or can Medaphyllin decrease milk supply in lactating mothers?
Medaphyllin lactation summary
- DrLact safety Score for Medaphyllin is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of Medaphyllin is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that Medaphyllin does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of Medaphyllin safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Medaphyllin usage in lactation
One case of nausea, vomiting and irritability has been described. However, Medaphyllin has been used as treatment of apnea on premature babies. It can enhance milk production by stimulating prolactin release.
Answer by DrLact: About Medaphyllin usage in lactation
An expert panel considers use of Medaphyllin to be acceptable during breastfeeding.[1] Maternal Medaphyllin use may occasionally cause stimulation and irritability and fretful sleep in infants. Newborn and especially preterm infants are most likely to be affected because of their slow elimination and low serum protein binding of Medaphyllin. There is no need to avoid Medaphyllin products; however, keep maternal serum concentrations in the lower part of the therapeutic range and monitor the infant for signs of Medaphyllin side effects. Infant serum Medaphyllin concentrations can help to determine if signs of agitation are due to Medaphyllin. Avoiding breastfeeding for an 2 hours after intravenous or 4 hours after an immediate-release oral Medaphyllin product can decrease the dose received by the breastfed infant. When Medaphyllin is given as an oral sustained-release product, timing of nursing with respect to the dose is of little or no benefit.
Medaphyllin Side Effects in Breastfeeding
Irritability and fretful sleeping occurred in a 3-day-old breastfed infant on days of maternal aminophylline intake of 200 mg every 6 hours. These effects ceased with discontinuation and recurred on rechallenge over the next 9 months. These effects were probably caused by Medaphyllin in breastmilk. Another five infants reported in this paper showed no adverse reactions after maternal Medaphyllin ingestion.[3] Accumulation of Medaphyllin in infant serum appears most likely in neonates and premature infants because they eliminate Medaphyllin slowly.[2][5]
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