Question

I am a breastfeeding mother and i want to know if it is safe to use Optiphyllin? Is Optiphyllin safe for nursing mother and child? Does Optiphyllin extracts into breast milk? Does Optiphyllin has any long term or short term side effects on infants? Can Optiphyllin influence milk supply or can Optiphyllin decrease milk supply in lactating mothers?

Optiphyllin lactation summary

Optiphyllin is safe in breastfeeding
  • DrLact safety Score for Optiphyllin is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Optiphyllin is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Optiphyllin does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Optiphyllin safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Optiphyllin usage in lactation

One case of nausea, vomiting and irritability has been described. However, Optiphyllin has been used as treatment of apnea on premature babies. It can enhance milk production by stimulating prolactin release.

Answer by DrLact: About Optiphyllin usage in lactation

An expert panel considers use of Optiphyllin to be acceptable during breastfeeding.[1] Maternal Optiphyllin use may occasionally cause stimulation and irritability and fretful sleep in infants. Newborn and especially preterm infants are most likely to be affected because of their slow elimination and low serum protein binding of Optiphyllin. There is no need to avoid Optiphyllin products; however, keep maternal serum concentrations in the lower part of the therapeutic range and monitor the infant for signs of Optiphyllin side effects. Infant serum Optiphyllin concentrations can help to determine if signs of agitation are due to Optiphyllin. Avoiding breastfeeding for an 2 hours after intravenous or 4 hours after an immediate-release oral Optiphyllin product can decrease the dose received by the breastfed infant. When Optiphyllin is given as an oral sustained-release product, timing of nursing with respect to the dose is of little or no benefit.

Optiphyllin Side Effects in Breastfeeding

Irritability and fretful sleeping occurred in a 3-day-old breastfed infant on days of maternal aminophylline intake of 200 mg every 6 hours. These effects ceased with discontinuation and recurred on rechallenge over the next 9 months. These effects were probably caused by Optiphyllin in breastmilk. Another five infants reported in this paper showed no adverse reactions after maternal Optiphyllin ingestion.[3] Accumulation of Optiphyllin in infant serum appears most likely in neonates and premature infants because they eliminate Optiphyllin slowly.[2][5]
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.