Is Purine-2,6(1H,3H)-dione, 1,3-dimethyl- Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Purine-2,6(1H,3H)-dione, 1,3-dimethyl-? Is Purine-2,6(1H,3H)-dione, 1,3-dimethyl- safe for nursing mother and child? Does Purine-2,6(1H,3H)-dione, 1,3-dimethyl- extracts into breast milk? Does Purine-2,6(1H,3H)-dione, 1,3-dimethyl- has any long term or short term side effects on infants? Can Purine-2,6(1H,3H)-dione, 1,3-dimethyl- influence milk supply or can Purine-2,6(1H,3H)-dione, 1,3-dimethyl- decrease milk supply in lactating mothers?

One case of nausea, vomiting and irritability has been described. However, Purine-2,6(1H,3H)-dione, 1,3-dimethyl- has been used as treatment of apnea on premature babies. It can enhance milk production by stimulating prolactin release.

An expert panel considers use of Purine-2,6(1H,3H)-dione, 1,3-dimethyl- to be acceptable during breastfeeding.[1] Maternal Purine-2,6(1H,3H)-dione, 1,3-dimethyl- use may occasionally cause stimulation and irritability and fretful sleep in infants. Newborn and especially preterm infants are most likely to be affected because of their slow elimination and low serum protein binding of Purine-2,6(1H,3H)-dione, 1,3-dimethyl-. There is no need to avoid Purine-2,6(1H,3H)-dione, 1,3-dimethyl- products; however, keep maternal serum concentrations in the lower part of the therapeutic range and monitor the infant for signs of Purine-2,6(1H,3H)-dione, 1,3-dimethyl- side effects. Infant serum Purine-2,6(1H,3H)-dione, 1,3-dimethyl- concentrations can help to determine if signs of agitation are due to Purine-2,6(1H,3H)-dione, 1,3-dimethyl-. Avoiding breastfeeding for an 2 hours after intravenous or 4 hours after an immediate-release oral Purine-2,6(1H,3H)-dione, 1,3-dimethyl- product can decrease the dose received by the breastfed infant. When Purine-2,6(1H,3H)-dione, 1,3-dimethyl- is given as an oral sustained-release product, timing of nursing with respect to the dose is of little or no benefit.

Irritability and fretful sleeping occurred in a 3-day-old breastfed infant on days of maternal aminophylline intake of 200 mg every 6 hours. These effects ceased with discontinuation and recurred on rechallenge over the next 9 months. These effects were probably caused by Purine-2,6(1H,3H)-dione, 1,3-dimethyl- in breastmilk. Another five infants reported in this paper showed no adverse reactions after maternal Purine-2,6(1H,3H)-dione, 1,3-dimethyl- ingestion.[3] Accumulation of Purine-2,6(1H,3H)-dione, 1,3-dimethyl- in infant serum appears most likely in neonates and premature infants because they eliminate Purine-2,6(1H,3H)-dione, 1,3-dimethyl- slowly.[2][5]