Is Synophylate-L.A. Cenules Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Synophylate-L.A. Cenules? Is Synophylate-L.A. Cenules safe for nursing mother and child? Does Synophylate-L.A. Cenules extracts into breast milk? Does Synophylate-L.A. Cenules has any long term or short term side effects on infants? Can Synophylate-L.A. Cenules influence milk supply or can Synophylate-L.A. Cenules decrease milk supply in lactating mothers?

One case of nausea, vomiting and irritability has been described. However, Synophylate-L.A. Cenules has been used as treatment of apnea on premature babies. It can enhance milk production by stimulating prolactin release.

An expert panel considers use of Synophylate-L.A. Cenules to be acceptable during breastfeeding.[1] Maternal Synophylate-L.A. Cenules use may occasionally cause stimulation and irritability and fretful sleep in infants. Newborn and especially preterm infants are most likely to be affected because of their slow elimination and low serum protein binding of Synophylate-L.A. Cenules. There is no need to avoid Synophylate-L.A. Cenules products; however, keep maternal serum concentrations in the lower part of the therapeutic range and monitor the infant for signs of Synophylate-L.A. Cenules side effects. Infant serum Synophylate-L.A. Cenules concentrations can help to determine if signs of agitation are due to Synophylate-L.A. Cenules. Avoiding breastfeeding for an 2 hours after intravenous or 4 hours after an immediate-release oral Synophylate-L.A. Cenules product can decrease the dose received by the breastfed infant. When Synophylate-L.A. Cenules is given as an oral sustained-release product, timing of nursing with respect to the dose is of little or no benefit.

Irritability and fretful sleeping occurred in a 3-day-old breastfed infant on days of maternal aminophylline intake of 200 mg every 6 hours. These effects ceased with discontinuation and recurred on rechallenge over the next 9 months. These effects were probably caused by Synophylate-L.A. Cenules in breastmilk. Another five infants reported in this paper showed no adverse reactions after maternal Synophylate-L.A. Cenules ingestion.[3] Accumulation of Synophylate-L.A. Cenules in infant serum appears most likely in neonates and premature infants because they eliminate Synophylate-L.A. Cenules slowly.[2][5]