Is Theo-Dur Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Theo-Dur? Is Theo-Dur safe for nursing mother and child? Does Theo-Dur extracts into breast milk? Does Theo-Dur has any long term or short term side effects on infants? Can Theo-Dur influence milk supply or can Theo-Dur decrease milk supply in lactating mothers?
Theo-Dur lactation summary
- DrLact safety Score for Theo-Dur is 1 out of 8 which is considered Safe as per our analyses.
- A safety Score of 1 indicates that usage of Theo-Dur is mostly safe during lactation for breastfed baby.
- Our study of different scientific research also indicates that Theo-Dur does not cause any serious side effects in breastfeeding mothers.
- Most of scientific studies and research papers declaring usage of Theo-Dur safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Theo-Dur usage in lactation
One case of nausea, vomiting and irritability has been described. However, Theo-Dur has been used as treatment of apnea on premature babies. It can enhance milk production by stimulating prolactin release.
Answer by DrLact: About Theo-Dur usage in lactation
An expert panel considers use of Theo-Dur to be acceptable during breastfeeding.[1] Maternal Theo-Dur use may occasionally cause stimulation and irritability and fretful sleep in infants. Newborn and especially preterm infants are most likely to be affected because of their slow elimination and low serum protein binding of Theo-Dur. There is no need to avoid Theo-Dur products; however, keep maternal serum concentrations in the lower part of the therapeutic range and monitor the infant for signs of Theo-Dur side effects. Infant serum Theo-Dur concentrations can help to determine if signs of agitation are due to Theo-Dur. Avoiding breastfeeding for an 2 hours after intravenous or 4 hours after an immediate-release oral Theo-Dur product can decrease the dose received by the breastfed infant. When Theo-Dur is given as an oral sustained-release product, timing of nursing with respect to the dose is of little or no benefit.
Theo-Dur Side Effects in Breastfeeding
Irritability and fretful sleeping occurred in a 3-day-old breastfed infant on days of maternal aminophylline intake of 200 mg every 6 hours. These effects ceased with discontinuation and recurred on rechallenge over the next 9 months. These effects were probably caused by Theo-Dur in breastmilk. Another five infants reported in this paper showed no adverse reactions after maternal Theo-Dur ingestion.[3] Accumulation of Theo-Dur in infant serum appears most likely in neonates and premature infants because they eliminate Theo-Dur slowly.[2][5]
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