Is Theophyl-225 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Theophyl-225? Is Theophyl-225 safe for nursing mother and child? Does Theophyl-225 extracts into breast milk? Does Theophyl-225 has any long term or short term side effects on infants? Can Theophyl-225 influence milk supply or can Theophyl-225 decrease milk supply in lactating mothers?

One case of nausea, vomiting and irritability has been described. However, Theophyl-225 has been used as treatment of apnea on premature babies. It can enhance milk production by stimulating prolactin release.

An expert panel considers use of Theophyl-225 to be acceptable during breastfeeding.[1] Maternal Theophyl-225 use may occasionally cause stimulation and irritability and fretful sleep in infants. Newborn and especially preterm infants are most likely to be affected because of their slow elimination and low serum protein binding of Theophyl-225. There is no need to avoid Theophyl-225 products; however, keep maternal serum concentrations in the lower part of the therapeutic range and monitor the infant for signs of Theophyl-225 side effects. Infant serum Theophyl-225 concentrations can help to determine if signs of agitation are due to Theophyl-225. Avoiding breastfeeding for an 2 hours after intravenous or 4 hours after an immediate-release oral Theophyl-225 product can decrease the dose received by the breastfed infant. When Theophyl-225 is given as an oral sustained-release product, timing of nursing with respect to the dose is of little or no benefit.

Irritability and fretful sleeping occurred in a 3-day-old breastfed infant on days of maternal aminophylline intake of 200 mg every 6 hours. These effects ceased with discontinuation and recurred on rechallenge over the next 9 months. These effects were probably caused by Theophyl-225 in breastmilk. Another five infants reported in this paper showed no adverse reactions after maternal Theophyl-225 ingestion.[3] Accumulation of Theophyl-225 in infant serum appears most likely in neonates and premature infants because they eliminate Theophyl-225 slowly.[2][5]