Is Argatroban Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Argatroban? Is Argatroban safe for nursing mother and child? Does Argatroban extracts into breast milk? Does Argatroban has any long term or short term side effects on infants? Can Argatroban influence milk supply or can Argatroban decrease milk supply in lactating mothers?

• DrLact safety Score for Argatroban is 5 out of 8 which is considered Unsafe as per our analyses.
• A safety Score of 5 indicates that usage of Argatroban may cause serious side effects in breastfed baby.
• Our study of different scientific research indicates that Argatroban may cause moderate to high side effects or may affect milk supply in lactating mother.
• Our suggestion is to use safer alternate options rather than using Argatroban .
• It is recommended to evaluate the advantage of not breastfeeding while using Argatroban Vs not using Argatroban And continue breastfeeding.
• While using Argatroban Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
• Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

On latest update relevant data on breastfeeding was not found. Absorption by the intestine is unknown. Although a better known and safer alternative is preferred, because of short half-life a delay of 3-4 hours period after last dose would permit to minimize any risk.

If argatroban is required by the mother, it is not a reason to discontinue breastfeeding, but because no information is available on the use of argatroban during breastfeeding, an alternate drug is preferred.[1]