Is Xanthine, 1,3-dimethyl- Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Xanthine, 1,3-dimethyl-? Is Xanthine, 1,3-dimethyl- safe for nursing mother and child? Does Xanthine, 1,3-dimethyl- extracts into breast milk? Does Xanthine, 1,3-dimethyl- has any long term or short term side effects on infants? Can Xanthine, 1,3-dimethyl- influence milk supply or can Xanthine, 1,3-dimethyl- decrease milk supply in lactating mothers?

One case of nausea, vomiting and irritability has been described. However, Xanthine, 1,3-dimethyl- has been used as treatment of apnea on premature babies. It can enhance milk production by stimulating prolactin release.

An expert panel considers use of Xanthine, 1,3-dimethyl- to be acceptable during breastfeeding.[1] Maternal Xanthine, 1,3-dimethyl- use may occasionally cause stimulation and irritability and fretful sleep in infants. Newborn and especially preterm infants are most likely to be affected because of their slow elimination and low serum protein binding of Xanthine, 1,3-dimethyl-. There is no need to avoid Xanthine, 1,3-dimethyl- products; however, keep maternal serum concentrations in the lower part of the therapeutic range and monitor the infant for signs of Xanthine, 1,3-dimethyl- side effects. Infant serum Xanthine, 1,3-dimethyl- concentrations can help to determine if signs of agitation are due to Xanthine, 1,3-dimethyl-. Avoiding breastfeeding for an 2 hours after intravenous or 4 hours after an immediate-release oral Xanthine, 1,3-dimethyl- product can decrease the dose received by the breastfed infant. When Xanthine, 1,3-dimethyl- is given as an oral sustained-release product, timing of nursing with respect to the dose is of little or no benefit.

Irritability and fretful sleeping occurred in a 3-day-old breastfed infant on days of maternal aminophylline intake of 200 mg every 6 hours. These effects ceased with discontinuation and recurred on rechallenge over the next 9 months. These effects were probably caused by Xanthine, 1,3-dimethyl- in breastmilk. Another five infants reported in this paper showed no adverse reactions after maternal Xanthine, 1,3-dimethyl- ingestion.[3] Accumulation of Xanthine, 1,3-dimethyl- in infant serum appears most likely in neonates and premature infants because they eliminate Xanthine, 1,3-dimethyl- slowly.[2][5]