Is UNII-0I55128JYK Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use UNII-0I55128JYK? Is UNII-0I55128JYK safe for nursing mother and child? Does UNII-0I55128JYK extracts into breast milk? Does UNII-0I55128JYK has any long term or short term side effects on infants? Can UNII-0I55128JYK influence milk supply or can UNII-0I55128JYK decrease milk supply in lactating mothers?

One case of nausea, vomiting and irritability has been described. However, UNII-0I55128JYK has been used as treatment of apnea on premature babies. It can enhance milk production by stimulating prolactin release.

An expert panel considers use of UNII-0I55128JYK to be acceptable during breastfeeding.[1] Maternal UNII-0I55128JYK use may occasionally cause stimulation and irritability and fretful sleep in infants. Newborn and especially preterm infants are most likely to be affected because of their slow elimination and low serum protein binding of UNII-0I55128JYK. There is no need to avoid UNII-0I55128JYK products; however, keep maternal serum concentrations in the lower part of the therapeutic range and monitor the infant for signs of UNII-0I55128JYK side effects. Infant serum UNII-0I55128JYK concentrations can help to determine if signs of agitation are due to UNII-0I55128JYK. Avoiding breastfeeding for an 2 hours after intravenous or 4 hours after an immediate-release oral UNII-0I55128JYK product can decrease the dose received by the breastfed infant. When UNII-0I55128JYK is given as an oral sustained-release product, timing of nursing with respect to the dose is of little or no benefit.

Irritability and fretful sleeping occurred in a 3-day-old breastfed infant on days of maternal aminophylline intake of 200 mg every 6 hours. These effects ceased with discontinuation and recurred on rechallenge over the next 9 months. These effects were probably caused by UNII-0I55128JYK in breastmilk. Another five infants reported in this paper showed no adverse reactions after maternal UNII-0I55128JYK ingestion.[3] Accumulation of UNII-0I55128JYK in infant serum appears most likely in neonates and premature infants because they eliminate UNII-0I55128JYK slowly.[2][5]