Question

I am a breastfeeding mother and i want to know if it is safe to use AI3-51923? Is AI3-51923 safe for nursing mother and child? Does AI3-51923 extracts into breast milk? Does AI3-51923 has any long term or short term side effects on infants? Can AI3-51923 influence milk supply or can AI3-51923 decrease milk supply in lactating mothers?

AI3-51923 lactation summary

AI3-51923 is unsafe in breastfeeding
  • DrLact safety Score for AI3-51923 is 5 out of 8 which is considered Unsafe as per our analyses.
  • A safety Score of 5 indicates that usage of AI3-51923 may cause serious side effects in breastfed baby.
  • Our study of different scientific research indicates that AI3-51923 may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using AI3-51923 .
  • It is recommended to evaluate the advantage of not breastfeeding while using AI3-51923 Vs not using AI3-51923 And continue breastfeeding.
  • While using AI3-51923 Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About AI3-51923 usage in lactation

No data on transfer into breastmilk are available. Withdrawn from the market in 2005 because of an increased risk of ventricular arrhytmias.

Answer by DrLact: About AI3-51923 usage in lactation

Because there is no published experience with AI3-51923 during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

AI3-51923 Possible Effects in Breastfeeding

Phenothiazines cause galactorrhea in 26 to 40% of female patients.[1][2] Hyperprolactinemia appears to be the cause of the galactorrhea.[3][4][5] There is some evidence that AI3-51923 increases serum prolactin to a greater extent than other phenothiazines.[6] The hyperprolactinemia is caused by the drug's dopamine-blocking action in the tuberoinfundibular pathway.[7] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.