Question

I am a breastfeeding mother and i want to know if it is safe to use 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine? Is 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine safe for nursing mother and child? Does 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine extracts into breast milk? Does 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine has any long term or short term side effects on infants? Can 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine influence milk supply or can 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine decrease milk supply in lactating mothers?

10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine lactation summary

10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine is unsafe in breastfeeding
  • DrLact safety Score for 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine is 5 out of 8 which is considered Unsafe as per our analyses.
  • A safety Score of 5 indicates that usage of 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine may cause serious side effects in breastfed baby.
  • Our study of different scientific research indicates that 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine .
  • It is recommended to evaluate the advantage of not breastfeeding while using 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine Vs not using 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine And continue breastfeeding.
  • While using 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine usage in lactation

No data on transfer into breastmilk are available. Withdrawn from the market in 2005 because of an increased risk of ventricular arrhytmias.

Answer by DrLact: About 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine usage in lactation

Because there is no published experience with 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine during breastfeeding, an alternate drug may be preferred, especially while nursing a newborn or preterm infant.

10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine Possible Effects in Breastfeeding

Phenothiazines cause galactorrhea in 26 to 40% of female patients.[1][2] Hyperprolactinemia appears to be the cause of the galactorrhea.[3][4][5] There is some evidence that 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine increases serum prolactin to a greater extent than other phenothiazines.[6] The hyperprolactinemia is caused by the drug's dopamine-blocking action in the tuberoinfundibular pathway.[7] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
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