Question

I am a breastfeeding mother and i want to know if it is safe to use P 4657B? Is P 4657B safe for nursing mother and child? Does P 4657B extracts into breast milk? Does P 4657B has any long term or short term side effects on infants? Can P 4657B influence milk supply or can P 4657B decrease milk supply in lactating mothers?

P 4657B lactation summary

P 4657B is unsafe in breastfeeding
  • DrLact safety Score for P 4657B is 5 out of 8 which is considered Unsafe as per our analyses.
  • A safety Score of 5 indicates that usage of P 4657B may cause serious side effects in breastfed baby.
  • Our study of different scientific research indicates that P 4657B may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using P 4657B .
  • It is recommended to evaluate the advantage of not breastfeeding while using P 4657B Vs not using P 4657B And continue breastfeeding.
  • While using P 4657B Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About P 4657B usage in lactation

No data on transfer into breastmilk are available.

Answer by DrLact: About P 4657B usage in lactation

Because there is no published experience with P 4657B during breastfeeding, other antipsychotic agents are preferred.

P 4657B Possible Effects in Breastfeeding

P 4657B has caused galactorrhea.[1] Hyperprolactinemia appears to be the cause of the galactorrhea.[2][3][4] The hyperprolactinemia is caused by the drug's dopamine-blocking action in the tuberoinfundibular pathway.[5] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.