Is Necitumumab Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Necitumumab? Is Necitumumab safe for nursing mother and child? Does Necitumumab extracts into breast milk? Does Necitumumab has any long term or short term side effects on infants? Can Necitumumab influence milk supply or can Necitumumab decrease milk supply in lactating mothers?

No information is available on the clinical use of necitumumab during breastfeeding. Because necitumumab is a large protein molecule with a molecular weight of 145,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. However, the manufacturer recommends that women receiving necitumumab should not breastfeed during therapy or for 3 months following the final dose. Necitumumab is a human immunoglobulin G1 (IgG1) kappa antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[3] None of the studies measured IgG activity.