Question

I am a breastfeeding mother and i want to know if it is safe to use Nilotinib? Is Nilotinib safe for nursing mother and child? Does Nilotinib extracts into breast milk? Does Nilotinib has any long term or short term side effects on infants? Can Nilotinib influence milk supply or can Nilotinib decrease milk supply in lactating mothers?

Nilotinib lactation summary

Nilotinib is unsafe in breastfeeding
  • DrLact safety Score for Nilotinib is 5 out of 8 which is considered Unsafe as per our analyses.
  • A safety Score of 5 indicates that usage of Nilotinib may cause serious side effects in breastfed baby.
  • Our study of different scientific research indicates that Nilotinib may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using Nilotinib .
  • It is recommended to evaluate the advantage of not breastfeeding while using Nilotinib Vs not using Nilotinib And continue breastfeeding.
  • While using Nilotinib Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Nilotinib usage in lactation

Inhibitor of BCR-ABL and SRC tyrosine kinase that is used for treatment of Chronic Myeloid Leukemia with positive Philadelphia chromosome. At latest update, relevant published data on excretion into breast milk were not found. Because of high serum protein-binding capacity, excretion into breast milk in significant amount is seemingly unlikely. If continuation of safely breastfeeding is desired without assuming high risk for potentially severe side-effects, elimination of total burden of drug should be kept. For this to happen, it should be wait for 10 half-lives (T ½). It means that 7 days should be waited before resuming breastfeeding. Meanwhile, frequent pump-and-dump is recommended for maintenance of milk production.

Answer by DrLact: About Nilotinib usage in lactation

Although the amount of nilotinib in milk appears to be small and one breastfed infants apparently experienced no adverse effects during maternal use of nilotinib, no long-term data are available. Because nilotinib is 98% bound to plasma proteins, the amounts in milk are likely to be low. However, there is little published experience with nilotinib during breastfeeding, and an alternate drug may be preferred, especially while nursing a newborn or preterm infant. The manufacturer recommends that breastfeeding be discontinued during nilotinib therapy and for 14 days after the last dose.

Nilotinib Side Effects in Breastfeeding

A woman with chronic myeloid leukemia received nilotinib (dosage not stated) for 20 months before pregnancy, throughout pregnancy and continuing during 9 months of breastfeeding (extent not stated). No adverse reactions were reported in her breastfed infant.[2]

Alternate Drugs

Dasatinib(Unsafe)
Fluorouracil(Dangerous)
Cisplatin(Unsafe)
Docetaxel(Dangerous)
Alemtuzumab(Low Risk)
Dactinomycin(Dangerous)
Busulfan(Dangerous)
Rituximab(Low Risk)
Gemcitabine(Dangerous)
Bevacizumab(Low Risk)
Thioguanine(Dangerous)
Nilotinib(Unsafe)
Pazopanib(Unsafe)
Vincristine(Dangerous)
Letrozole(Dangerous)
Tamoxifen(Dangerous)
Erlotinib(Unsafe)
Trastuzumab(Unsafe)
Exemestane(Dangerous)
Mitoxantrone(Dangerous)
Cladribine(Dangerous)
Nivolumab(Unsafe)
Vinblastine(Dangerous)
Ipilimumab(Unsafe)
Hydroxyurea(Low Risk)
Cetuximab(Unsafe)
Etoposide(Dangerous)
Bleomycin(Dangerous)
Imatinib(Unsafe)
Carboplatin(Dangerous)
Doxorubicin(Dangerous)
Vinorelbine(Dangerous)
Paclitaxel(Dangerous)
Cyclophosphamide(Dangerous)
Dacarbazine(Dangerous)
Gemcitabine(Dangerous)
Orlistat(Low Risk)
Nilotinib(Unsafe)
Pazopanib(Unsafe)
Erlotinib(Unsafe)
Imatinib(Unsafe)
Dasatinib(Unsafe)
Nilotinib(Unsafe)
Pazopanib(Unsafe)
Erlotinib(Unsafe)
Imatinib(Unsafe)
Dasatinib(Unsafe)
Nilotinib(Unsafe)
Pazopanib(Unsafe)
Erlotinib(Unsafe)
Imatinib(Unsafe)
Dasatinib(Unsafe)
Nilotinib(Unsafe)
Pazopanib(Unsafe)
Erlotinib(Unsafe)
Imatinib(Unsafe)
Dasatinib(Unsafe)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.