Is Deferasirox Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Deferasirox? Is Deferasirox safe for nursing mother and child? Does Deferasirox extracts into breast milk? Does Deferasirox has any long term or short term side effects on infants? Can Deferasirox influence milk supply or can Deferasirox decrease milk supply in lactating mothers?

Deferasirox appears to pass into milk very poorly. Although Australian guidelines recommend against breastfeeding during deferasirox treatment,[1] these were published before a case report of an infant being safely breastfed by a mother with beta-thalassemia receiving deferasirox and finding of no drug in breastmilk.[2] If deferasirox is required by the mother, it is not a reason to discontinue breastfeeding. However, since little published information is available on the use of deferasirox during breastfeeding, monitoring of the infant's serum iron is recommended.

A woman with beta-thalassemia was started on deferasirox 2250 mg (35 mg/kg) daily immediately postpartum and exclusively breastfed her infant. Blood samples were taken from the infant at 1, 10 and 30 days postpartum. Serum ferritin levels were 190, 218, and 96 mcg/L, respectively (normal range 22-275 mcg/L). Serum iron levels were 101, 77 and 71 mcg/dL, respectively (normal range 60-170 mcg/dL). The infant's growth was normal during the first month at the 41st percentile.[2]