Is Cladribine Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Cladribine? Is Cladribine safe for nursing mother and child? Does Cladribine extracts into breast milk? Does Cladribine has any long term or short term side effects on infants? Can Cladribine influence milk supply or can Cladribine decrease milk supply in lactating mothers?
Cladribine lactation summary
- DrLact safety Score for Cladribine is 7 out of 8 which is considered Dangerous as per our analyses.
- A safety Score of 7 indicates that usage of Cladribine may cause toxic or severe side effects in breastfed baby.
- Our study of different scientific research indicates that Cladribine may cause moderate to high side effects or may affect milk supply in lactating mother.
- Our suggestion is to use safer alternate options rather than using Cladribine .
- Usage of Cladribine is in contradiction to breastfeeding hence if it is must to use Cladribine and there is no better alternative available then breastfeeding shall be stopped permanently or temporarily.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Cladribine usage in lactation
Drug is cleared from the body in 7 elimination half-lives. Resuming breastfeeding is likely safe after 48 hours of pumping-and-dumping.
Answer by DrLact: About Cladribine usage in lactation
Because there is no published experience with cladribine during breastfeeding, it should be avoided during breastfeeding, especially while nursing a newborn or preterm infant.[1][2] One group of authors recommends withholding breastfeeding for at 48 hours after a dose and longer in patients with impaired kidney function.[2] Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[3] Women who receive chemotherapy during pregnancy are more likely to have difficulty nursing their infant.[4]
Alternate Drugs
Cetuximab(Unsafe)
Pazopanib(Unsafe)
Cisplatin(Unsafe)
Docetaxel(Dangerous)
Carboplatin(Dangerous)
Busulfan(Dangerous)
Vinblastine(Dangerous)
Azelaic Acid(Safe)
Paclitaxel(Dangerous)
Bleomycin(Dangerous)
Vinorelbine(Dangerous)
Erlotinib(Unsafe)
Dacarbazine(Dangerous)
Vincristine(Dangerous)
Fluorouracil(Dangerous)
Tamoxifen(Dangerous)
Cladribine(Dangerous)
Letrozole(Dangerous)
Exemestane(Dangerous)
Alemtuzumab(Low Risk)
Dactinomycin(Dangerous)
Thioguanine(Dangerous)
Mitoxantrone(Dangerous)
Dasatinib(Unsafe)
Rituximab(Low Risk)
Nilotinib(Unsafe)
Mercaptopurine(Safe)
Bevacizumab(Low Risk)
Hydroxyurea(Low Risk)
Etoposide(Dangerous)
Gemcitabine(Dangerous)
Doxorubicin(Dangerous)
Trastuzumab(Unsafe)
Nivolumab(Unsafe)
Imatinib(Unsafe)
Ipilimumab(Unsafe)
Cyclophosphamide(Dangerous)
Pimecrolimus(Low Risk)
Azathioprine(Safe)
Methotrexate(Low Risk)
Fluorouracil(Dangerous)
Cladribine(Dangerous)
Alemtuzumab(Low Risk)
Tacrolimus(Safe)
Mercaptopurine(Safe)
Fingolimod(Unsafe)
Sirolimus(Unsafe)
Gemcitabine(Dangerous)
Everolimus(Unsafe)
Leflunomide(Dangerous)
Cyclosporine(Safe)
Dimethyl fumarate(Low Risk)