Is Daclatasvir Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Daclatasvir? Is Daclatasvir safe for nursing mother and child? Does Daclatasvir extracts into breast milk? Does Daclatasvir has any long term or short term side effects on infants? Can Daclatasvir influence milk supply or can Daclatasvir decrease milk supply in lactating mothers?
Daclatasvir lactation summary
- DrLact safety Score for Daclatasvir is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of Daclatasvir may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that Daclatasvir may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of Daclatasvir low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using Daclatasvir We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About Daclatasvir usage in lactation
Usually used alone or in combination with sofosbuvir in the treatment of hepatitis C. Since the last update we have not found published data on its excretion in breast milk. Its pharmacokinetic data (high molecular weight and very high percentage of plasma protein binding) make it very unlikely that significant amounts will pass into breast milk, so that, although there is disagreement (Thompson 2016), some authors consider that treatment with Daclatasvir, alone or in combination with sofosbuvir is not contraindicated during breastfeeding (Spera 2016, LactMed 2016). See below the information of these related products:
Answer by DrLact: About Daclatasvir usage in lactation
Daclatasvir has not been studied in nursing mothers being treated for hepatitis C infection. Because it is 99% bound to maternal plasma proteins, amounts in breastmilk are likely to be very low. If daclatasvir used alone or in combination with sofosbuvir is required by the mother, it is not a reason to discontinue breastfeeding.[1] Some sources recommend against breastfeeding when daclatasvir is used with ribavirin. Hepatitis C is not transmitted through breastmilk[2][3] and breastmilk has been shown to inactivate hepatitis C virus (HCV).[4][5] However, the Centers for Disease Control recommends that mothers with HCV infection should consider abstaining from breastfeeding if their nipples are cracked or bleeding. It is not clear if this warning would apply to mothers who are being treated for hepatitis C. Infants born to mothers with HCV infection should be tested for HCV infection; because maternal antibody is present for the first 18 months of life and before the infant mounts an immunologic response, nucleic acid testing is recommended.[2][3]
Alternate Drugs
Didanosine(Unsafe)
Ganciclovir(Low Risk)
Tenofovir(Safe)
Velpatasvir(Low Risk)
Saquinavir(Unsafe)
Simeprevir(Low Risk)
Ritonavir(Unsafe)
Ribavirin(Low Risk)
Abacavir(Safe)
Sofosbuvir(Low Risk)
Oseltamivir(Safe)
Nevirapine(Low Risk)
Amantadine(Low Risk)
Nelfinavir(Unsafe)
Ledipasvir(Low Risk)
Penciclovir(Safe)
Famciclovir(Low Risk)
Lamivudine(Safe)
Acyclovir(Safe)
Ombitasvir(Low Risk)
Indinavir(Unsafe)
Daclatasvir(Low Risk)
Emtricitabine(Safe)
Zanamivir(Safe)
Dasabuvir(Low Risk)
Efavirenz(Unsafe)
Valganciclovir(Low Risk)
Zidovudine(Low Risk)
Velpatasvir(Low Risk)
Ledipasvir(Low Risk)
Ombitasvir(Low Risk)
Daclatasvir(Low Risk)