Question

I am a breastfeeding mother and i want to know if it is safe to use NSC 17474? Is NSC 17474 safe for nursing mother and child? Does NSC 17474 extracts into breast milk? Does NSC 17474 has any long term or short term side effects on infants? Can NSC 17474 influence milk supply or can NSC 17474 decrease milk supply in lactating mothers?

NSC 17474 lactation summary

NSC 17474 is safe in breastfeeding
  • DrLact safety Score for NSC 17474 is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of NSC 17474 is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that NSC 17474 does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of NSC 17474 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About NSC 17474 usage in lactation

Tranquillizer drug similar to prochlorperazine that may produce galactorrhea by increasing prolactin release.

Answer by DrLact: About NSC 17474 usage in lactation

Limited information indicates that maternal doses of NSC 17474 up to 10 mg daily do not affect the breastfed infant. Very limited long-term follow-up data indicate no adverse developmental effects when other phenothiazines are used alone. Because there is little published experience with NSC 17474 during breastfeeding, other antipsychotic agents may be preferred, especially wile nursing an newborn or preterm infant.

NSC 17474 Side Effects in Breastfeeding

One infant was breastfed from birth during maternal NSC 17474 10 mg daily in addition to clonazepam 0.25 mg daily and valproic acid 500 mg daily. No adverse effects in the infant were reported by the mother (follow-up time unspecified).[2] One mother began taking NSC 17474 (dosage unspecified) 2 months postpartum while breastfeeding her infant. She also started olanzapine 10 mg daily, paroxetine and procyclidine (dosages unspecified). The infant experiences no adverse reactions.[3] Two mothers taking NSC 17474 5 and 10 mg per day orally breastfed their infants from 1 week and 8 weeks of age, respectively. Mental and psychomotor development were measured at various time up to 30 months of age and were found to be normal.[1]

NSC 17474 Possible Effects in Breastfeeding

Phenothiazines cause galactorrhea in 26 to 40% of female patients.[4][5] Hyperprolactinemia appears to be the cause of the galactorrhea.[6][7][8] The hyperprolactinemia is caused by the drug's dopamine-blocking action in the tuberoinfundibular pathway.[9]
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.