Question

I am a breastfeeding mother and i want to know if it is safe to use Paritaprevir? Is Paritaprevir safe for nursing mother and child? Does Paritaprevir extracts into breast milk? Does Paritaprevir has any long term or short term side effects on infants? Can Paritaprevir influence milk supply or can Paritaprevir decrease milk supply in lactating mothers?

Answer by DrLact: About Paritaprevir usage in lactation

Paritaprevir has not been studied in nursing mothers being treated for hepatitis C infection. Because it is greater than 97% bound to maternal plasma proteins, amounts in breastmilk are likely to be very low. If paritaprevir used alone or in combination with ombitasvir and ritonavir (Technivie) or with ombitasvir, desabuvir and ritonavir (Viekira Pak) is required by the mother, it is not a reason to discontinue breastfeeding. Some sources recommend against breastfeeding when paritaprevir is used with ribavirin. Hepatitis C is not transmitted through breastmilk[1][2] and breastmilk has been shown to inactivate hepatitis C virus (HCV).[3][4] However, the Centers for Disease Control recommends that mothers with HCV infection should consider abstaining from breastfeeding if their nipples are cracked or bleeding. It is not clear if this warning would apply to mothers who are being treated for hepatitis C. Infants born to mothers with HCV infection should be tested for HCV infection; because maternal antibody is present for the first 18 months of life and before the infant mounts an immunologic response, nucleic acid testing is recommended.[1][2]
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.