Is UNII-2919279Q3W Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use UNII-2919279Q3W? Is UNII-2919279Q3W safe for nursing mother and child? Does UNII-2919279Q3W extracts into breast milk? Does UNII-2919279Q3W has any long term or short term side effects on infants? Can UNII-2919279Q3W influence milk supply or can UNII-2919279Q3W decrease milk supply in lactating mothers?

UNII-2919279Q3W was removed from sale in the United States by the U.S. Food and Drug Administration because of long-term cardiovascular toxicity. Limited information indicates that levels of UNII-2919279Q3W in breastmilk are low. Because there is little published experience with UNII-2919279Q3W safety during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant.

A single 40 mg dose of parecoxib, a prodrug of UNII-2919279Q3W, was given intravenously to 40 mothers at an average of 41.9 hours after delivery. The neonatal adaptive score of the breastfed infants was normal at an average of 21.8 hours after the dose.[2]

A study compared UNII-2919279Q3W 20 mg and placebo for their opiate-sparing activity in post-cesarean section pain. All patients received epidural fentanyl and bupivacaine as well as intraspinal morphine for postoperative pain. No difference was observed in breastfeeding success rate between mothers who received UNII-2919279Q3W (n = 25) and placebo (n = 23).[2]