Question

I am a breastfeeding mother and i want to know if it is safe to use Aflibercept? Is Aflibercept safe for nursing mother and child? Does Aflibercept extracts into breast milk? Does Aflibercept has any long term or short term side effects on infants? Can Aflibercept influence milk supply or can Aflibercept decrease milk supply in lactating mothers?

Answer by DrLact: About Aflibercept usage in lactation

This record refers to the use of intravitreal aflibercept for macular degeneration. No information is available on the use of aflibercept during breastfeeding. The manufacturer estimates that after intravitreal administration of 2 mg, the mean maximum plasma concentration of free aflibercept is more than 100-fold lower than the concentration of aflibercept required to half-maximally bind systemic vascular endothelial growth factor. Additionally, aflibercept is a large protein molecule with a molecular weight of 115,000, Therefore, the amount in breastmilk is likely to be clinically unimportant after intravitreal injection. However, the manufacturer recommends avoiding the drug during breastfeeding.
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