Is NSC-67574 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use NSC-67574? Is NSC-67574 safe for nursing mother and child? Does NSC-67574 extracts into breast milk? Does NSC-67574 has any long term or short term side effects on infants? Can NSC-67574 influence milk supply or can NSC-67574 decrease milk supply in lactating mothers?
NSC-67574 lactation summary
- DrLact safety Score for NSC-67574 is 7 out of 8 which is considered Dangerous as per our analyses.
- A safety Score of 7 indicates that usage of NSC-67574 may cause toxic or severe side effects in breastfed baby.
- Our study of different scientific research indicates that NSC-67574 may cause moderate to high side effects or may affect milk supply in lactating mother.
- Our suggestion is to use safer alternate options rather than using NSC-67574 .
- Usage of NSC-67574 is in contradiction to breastfeeding hence if it is must to use NSC-67574 and there is no better alternative available then breastfeeding shall be stopped permanently or temporarily.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About NSC-67574 usage in lactation
Drug is cleared from the body in 5 elimination half-lives. Return to breastfeeding is likely safe after 35 days of pumping-discarding of the milk.
Answer by DrLact: About NSC-67574 usage in lactation
Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy.[1] It is probably impractical to resume breastfeeding after NSC-67574 therapy because of the drug's long half-life. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[2]
NSC-67574 Side Effects in Breastfeeding
In a 4-month-old, neutropenia was probably caused by cyclophosphamide in a mother 9 days after the last of 6 weekly doses of 800 mg cyclophosphamide intravenously, 2 mg NSC-67574 intravenously and daily doses of 30 mg of prednisolone orally. Neutropenia persisted at least 12 days and was accompanied by a brief episode of diarrhea.[3] The contribution of NSC-67574 to the neutropenia cannot be determined.
Alternate Drugs
Carboplatin(Dangerous)
Hydroxyurea(Low Risk)
Paclitaxel(Dangerous)
Etoposide(Dangerous)
Fluorouracil(Dangerous)
Gemcitabine(Dangerous)
Alemtuzumab(Low Risk)
Nivolumab(Unsafe)
Doxorubicin(Dangerous)
Rituximab(Low Risk)
Vinblastine(Dangerous)
Cyclophosphamide(Dangerous)
Bevacizumab(Low Risk)
Bleomycin(Dangerous)
Docetaxel(Dangerous)
Cisplatin(Unsafe)
Pazopanib(Unsafe)
Vinorelbine(Dangerous)
Busulfan(Dangerous)
Trastuzumab(Unsafe)
Dacarbazine(Dangerous)
Imatinib(Unsafe)
Thioguanine(Dangerous)
Azelaic Acid(Safe)
Erlotinib(Unsafe)
Cladribine(Dangerous)
Letrozole(Dangerous)
Exemestane(Dangerous)
Vincristine(Dangerous)
Dasatinib(Unsafe)
Tamoxifen(Dangerous)
Nilotinib(Unsafe)
Mitoxantrone(Dangerous)
Dactinomycin(Dangerous)
Ipilimumab(Unsafe)
Mercaptopurine(Safe)
Cetuximab(Unsafe)