Is NSC-67574 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use NSC-67574? Is NSC-67574 safe for nursing mother and child? Does NSC-67574 extracts into breast milk? Does NSC-67574 has any long term or short term side effects on infants? Can NSC-67574 influence milk supply or can NSC-67574 decrease milk supply in lactating mothers?
NSC-67574 lactation summary
- DrLact safety Score for NSC-67574 is 7 out of 8 which is considered Dangerous as per our analyses.
- A safety Score of 7 indicates that usage of NSC-67574 may cause toxic or severe side effects in breastfed baby.
- Our study of different scientific research indicates that NSC-67574 may cause moderate to high side effects or may affect milk supply in lactating mother.
- Our suggestion is to use safer alternate options rather than using NSC-67574 .
- Usage of NSC-67574 is in contradiction to breastfeeding hence if it is must to use NSC-67574 and there is no better alternative available then breastfeeding shall be stopped permanently or temporarily.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About NSC-67574 usage in lactation
Drug is cleared from the body in 5 elimination half-lives. Return to breastfeeding is likely safe after 35 days of pumping-discarding of the milk.
Answer by DrLact: About NSC-67574 usage in lactation
Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy.[1] It is probably impractical to resume breastfeeding after NSC-67574 therapy because of the drug's long half-life. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[2]
NSC-67574 Side Effects in Breastfeeding
In a 4-month-old, neutropenia was probably caused by cyclophosphamide in a mother 9 days after the last of 6 weekly doses of 800 mg cyclophosphamide intravenously, 2 mg NSC-67574 intravenously and daily doses of 30 mg of prednisolone orally. Neutropenia persisted at least 12 days and was accompanied by a brief episode of diarrhea.[3] The contribution of NSC-67574 to the neutropenia cannot be determined.
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