Is Vincrystine Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Vincrystine? Is Vincrystine safe for nursing mother and child? Does Vincrystine extracts into breast milk? Does Vincrystine has any long term or short term side effects on infants? Can Vincrystine influence milk supply or can Vincrystine decrease milk supply in lactating mothers?

Drug is cleared from the body in 5 elimination half-lives. Return to breastfeeding is likely safe after 35 days of pumping-discarding of the milk.

Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy.[1] It is probably impractical to resume breastfeeding after Vincrystine therapy because of the drug's long half-life. Chemotherapy may adversely affect the normal microbiome and chemical makeup of breastmilk.[2]

In a 4-month-old, neutropenia was probably caused by cyclophosphamide in a mother 9 days after the last of 6 weekly doses of 800 mg cyclophosphamide intravenously, 2 mg Vincrystine intravenously and daily doses of 30 mg of prednisolone orally. Neutropenia persisted at least 12 days and was accompanied by a brief episode of diarrhea.[3] The contribution of Vincrystine to the neutropenia cannot be determined.