Is Cobimetinib Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Cobimetinib? Is Cobimetinib safe for nursing mother and child? Does Cobimetinib extracts into breast milk? Does Cobimetinib has any long term or short term side effects on infants? Can Cobimetinib influence milk supply or can Cobimetinib decrease milk supply in lactating mothers?
Answer by DrLact: About Cobimetinib usage in lactation
No information is available on the clinical use of cobimetinib during breastfeeding. Because cobimetinib is 90% bound to plasma proteins, the amount in milk is likely to be low. However, its half-life is about 44 hours and it might accumulate in the infant. The manufacturer recommends that breastfeeding be discontinued during cobimetinib therapy and for 2 weeks after the last dose.
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