I am a breastfeeding mother and i want to know if it is safe to use Regorafenib? Is Regorafenib safe for nursing mother and child? Does Regorafenib extracts into breast milk? Does Regorafenib has any long term or short term side effects on infants? Can Regorafenib influence milk supply or can Regorafenib decrease milk supply in lactating mothers?
No information is available on the clinical use of regorafenib during breastfeeding. Because regorafenib is 99.5% bound to plasma proteins, the amount in milk is likely to be low. However, one of its metabolites has a half-life of up to 70 hours, and might accumulate in the infant. The manufacturer recommends that breastfeeding be discontinued during regorafenib therapy and for 2 weeks after the final dose.