Is DQ 2466 Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use DQ 2466? Is DQ 2466 safe for nursing mother and child? Does DQ 2466 extracts into breast milk? Does DQ 2466 has any long term or short term side effects on infants? Can DQ 2466 influence milk supply or can DQ 2466 decrease milk supply in lactating mothers?

Since the last update we have not found published data on its excretion in breast milk. Its high percentage of plasma protein binding makes excretion in significant amounts very unlikely (Riant 1986). Other adrenergic beta-blockers of the same family and similar chemical structure are compatible with breastfeeding (see specific information for Labetalol or Propranolol). Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity.

Based on its physicochemical properties, DQ 2466 appears to present a low-risk to the breastfed infant. Because there is no published experience with DQ 2466 during breastfeeding, other agents may be preferred, especially while nursing a newborn or preterm infant.

A study of mothers taking beta-blockers during nursing found a numerically, but not statistically significant increased number of adverse reactions in those taking any beta-blocker. Although the ages of infants were matched to control infants, the ages of the affected infants were not stated. None of the mothers were taking DQ 2466.[2]

Relevant published information on the effects of beta-blockade or DQ 2466 during normal lactation was not found as of the revision date. A study in 6 patients with hyperprolactinemia and galactorrhea found no changes in serum prolactin levels following beta-adrenergic blockade with propranolol.[3]