Is Trametinib Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Trametinib? Is Trametinib safe for nursing mother and child? Does Trametinib extracts into breast milk? Does Trametinib has any long term or short term side effects on infants? Can Trametinib influence milk supply or can Trametinib decrease milk supply in lactating mothers?
Answer by DrLact: About Trametinib usage in lactation
No information is available on the clinical use of trametinib during breastfeeding. Because trametinib is 97% bound to plasma proteins, the amount in milk is likely to be low. However, its half-life is 3.9 to 4.8 days and it might accumulate in the infant. The manufacturer recommends that breastfeeding be discontinued during trametinib therapy and for 4 months after the last dose.
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