Question

I am a breastfeeding mother and i want to know if it is safe to use Nivaquine? Is Nivaquine safe for nursing mother and child? Does Nivaquine extracts into breast milk? Does Nivaquine has any long term or short term side effects on infants? Can Nivaquine influence milk supply or can Nivaquine decrease milk supply in lactating mothers?

Nivaquine lactation summary

Nivaquine is safe in breastfeeding
  • DrLact safety Score for Nivaquine is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of Nivaquine is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that Nivaquine does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of Nivaquine safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About Nivaquine usage in lactation

No adverse effect has been described. Anti-malarial drug used for anti-inflammatory and immune suppressive medication on collagen diseases like idiopathic arthritis or lupus. After a dose of 5 mg per kilo taken by the mother only 0.2 mg is secreted into breast milk. This amount would not be harmful for the child since the dose to a child as chemo-prophylaxis for malaria is 8 mg per kilo each week. Avoid using it in patients suffering G-6-P-dehydrogenasa. American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.

Answer by DrLact: About Nivaquine usage in lactation

Very small amounts of Nivaquine are excreted in breast milk; when given once weekly, the amount of drug is not sufficient to harm the infant nor is the quantity sufficient to protect the child from malaria. United Kingdom malaria treatment guidelines recommend that weekly Nivaquine 500 mg be given until breastfeeding is completed and primaquine can be given.[1] Breastfeeding infants should receive the recommended dosages of Nivaquine for malaria prophylaxis.[2] In HIV-infected women, elevated viral HIV loads in milk were decreased after treatment with Nivaquine to a greater extent than other women who were treated with the combination of sulfadoxine and pyrimethamine.[3] Because no information is available on the daily use of Nivaquine during breastfeeding, hydroxyNivaquine or another agent may be preferred in this situation, especially while nursing a newborn or preterm infant.

Nivaquine Side Effects in Breastfeeding

Several authors have pointed out that malaria prophylaxis in nursing mothers with Nivaquine is common in endemic areas.[7][8][9] As of the revision date, no reports of adverse reactions in breastfed infants have been published.

Alternate Drugs

Linezolid(Low Risk)
Cefoxitin(Safe)
Ritonavir(Unsafe)
Neomycin(Safe)
Cefotetan(Safe)
Abacavir(Safe)
Valganciclovir(Low Risk)
Enoxacin(Low Risk)
Ganciclovir(Low Risk)
Doxycycline(Low Risk)
Nevirapine(Low Risk)
Rifaximin(Safe)
Nafcillin(Safe)
Nelfinavir(Unsafe)
Moxifloxacin(Low Risk)
Cefixime(Safe)
Demeclocycline(Low Risk)
Amikacin(Safe)
Naftifine(Safe)
Famciclovir(Low Risk)
Cefepime(Safe)
Methicillin(Low Risk)
Malathion(Low Risk)
Erythromycin(Low Risk)
Meropenem(Safe)
Dapsone(Low Risk)
Clindamycin(Low Risk)
Cefdinir(Safe)
Indinavir(Unsafe)
Capreomycin(Low Risk)
Cefazolin(Safe)
Lomefloxacin(Low Risk)
Ertapenem(Safe)
Levofloxacin(Low Risk)
Zidovudine(Low Risk)
Cefaclor(Safe)
Primaquine(Low Risk)
Kanamycin(Safe)
Acyclovir(Safe)
Tenofovir(Safe)
Econazole(Safe)
Efavirenz(Unsafe)
Didanosine(Unsafe)
Amantadine(Low Risk)
Cefprozil(Safe)
Lindane(Unsafe)
Quinine(Safe)
Aztreonam(Safe)
Ofloxacin(Safe)
Atovaquone(Low Risk)
Gatifloxacin(Low Risk)
Saquinavir(Unsafe)
Primaquine(Low Risk)
Quinine(Safe)
Atovaquone(Low Risk)
Malathion(Low Risk)
Primaquine(Low Risk)
Pyrantel(Safe)
Lindane(Unsafe)
Quinine(Safe)
Atovaquone(Low Risk)
Primaquine(Low Risk)
Quinine(Safe)
Atovaquone(Low Risk)
Methotrexate(Low Risk)
Anakinra(Low Risk)
Abatacept(Low Risk)
Rituximab(Low Risk)
Leflunomide(Dangerous)
Penicillamine(Low Risk)
Tocilizumab(Low Risk)
Auranofin(Low Risk)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.