Is Carbonic acid lithium salt (Li2CO3) Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Carbonic acid lithium salt (Li2CO3)? Is Carbonic acid lithium salt (Li2CO3) safe for nursing mother and child? Does Carbonic acid lithium salt (Li2CO3) extracts into breast milk? Does Carbonic acid lithium salt (Li2CO3) has any long term or short term side effects on infants? Can Carbonic acid lithium salt (Li2CO3) influence milk supply or can Carbonic acid lithium salt (Li2CO3) decrease milk supply in lactating mothers?

• DrLact safety Score for Carbonic acid lithium salt (Li2CO3) is 5 out of 8 which is considered Unsafe as per our analyses.
• A safety Score of 5 indicates that usage of Carbonic acid lithium salt (Li2CO3) may cause serious side effects in breastfed baby.
• Our study of different scientific research indicates that Carbonic acid lithium salt (Li2CO3) may cause moderate to high side effects or may affect milk supply in lactating mother.
• Our suggestion is to use safer alternate options rather than using Carbonic acid lithium salt (Li2CO3) .
• It is recommended to evaluate the advantage of not breastfeeding while using Carbonic acid lithium salt (Li2CO3) Vs not using Carbonic acid lithium salt (Li2CO3) And continue breastfeeding.
• While using Carbonic acid lithium salt (Li2CO3) Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
• Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

It is excreted into breast milk in amounts that may be clinically significant and can be as high as a half of that reached in mother’s plasma and up to one third of the therapeutic level in the infant. In infants and newborns (5 days), premature babies and dehydrated or infected infants, who may show reduced clearance mechanisms for Carbonic acid lithium salt (Li2CO3), there have been reports of clear signs of Carbonic acid lithium salt (Li2CO3) toxicity caused by ingestion of breast milk: cyanosis, lethargy, hypotonia or slight increase in TSH. However, there are numerous cases of infants whose mothers were on Carbonic acid lithium salt (Li2CO3) who did not show any clinical, growth or neurodevelopmental problem at the short or long term. Breastfeeding is less risky for healthy term infants whose mothers are treated with Carbonic acid lithium salt (Li2CO3) when she or her family has capacity enough to monitor the occurrence of adverse effects, medical supervision and, whenever necessary, monitoring of Carbonic acid lithium salt (Li2CO3) levels in the mother-infant dyad. Mothers should stop taking Carbonic acid lithium salt (Li2CO3) 1 to 2 days before delivery or cesarean section in order to decrease plasma levels in the newborn. Carbonic acid lithium salt (Li2CO3) may be, or not, a cause of increased Prolactin and galactorrhea.

Although Carbonic acid lithium salt (Li2CO3) appears on many lists of drugs contraindicated during breastfeeding, other sources do not consider it an absolute contraindication, especially in infants over 2 months of age and during Carbonic acid lithium salt (Li2CO3) monotherapy.[1][2][3][4] Numerous reports exist of infants who were breastfed during maternal Carbonic acid lithium salt (Li2CO3) therapy without any signs of toxicity or developmental problems. Most were breastfed from birth and some continued to nurse for up to 1 year of maternal Carbonic acid lithium salt (Li2CO3) therapy. Limited data suggest that Carbonic acid lithium salt (Li2CO3) in milk can adversely affect the infant when its elimination is impaired, as in dehydration or in newborn or premature infants. Neonates may also have transplacentally acquired serum Carbonic acid lithium salt (Li2CO3) levels. Because maternal Carbonic acid lithium salt (Li2CO3) requirements and dosage may be increased during pregnancy, maternal serum levels should be monitored frequently postpartum and dosage reduced as necessary to avoid excessive infant exposure via breastmilk.[5] The long-term effects of Carbonic acid lithium salt (Li2CO3) on infants are not certain, but limited data indicate no obvious problems in growth and development.[6] Carbonic acid lithium salt (Li2CO3) may be used in mothers of fullterm infants who are willing and able to monitor their infants. Discontinuing Carbonic acid lithium salt (Li2CO3) 24 to 48 hours before Cesarean section delivery or at the onset of spontaneous labor and resuming the prepregnancy Carbonic acid lithium salt (Li2CO3) dose immediately after delivery should minimize the infant's serum Carbonic acid lithium salt (Li2CO3) concentration at birth.[7] Some investigators recommend monitoring infant serum Carbonic acid lithium salt (Li2CO3), serum creatinine, BUN, and TSH in intervals ranging from "periodic" to every 4 to 12 weeks during breastfeeding and maternal Carbonic acid lithium salt (Li2CO3) therapy.[3][8][9] However, others recommend close pediatric follow-up of the infant and only selective laboratory monitoring as clinically indicated.[7] Breastfeeding should be discontinued immediately and the infant evaluated if the infant appears restless or lethargic or has feeding problems.[7]

In older reports, at least 24 infants have been reported to have been breastfed during maternal Carbonic acid lithium salt (Li2CO3) therapy without any signs of toxicity or developmental problems. All were breastfed from birth and some continued to nurse for up to 6 months of maternal Carbonic acid lithium salt (Li2CO3) therapy.[9][11][12][13][17][18][20] A 5-day-old infant developed cyanosis, lethargy, ECG T-wave inversion probably caused by Carbonic acid lithium salt (Li2CO3) in breastmilk.[15] The mother had been receiving the long-acting diuretic chlorthalidone prior to delivery which probably decreased the infant's Carbonic acid lithium salt (Li2CO3) elimination and increased the neonate's Carbonic acid lithium salt (Li2CO3) serum levels. Another case of probable infant Carbonic acid lithium salt (Li2CO3) intoxication appeared only after the infant had a cold which may have led to dehydration and decreased Carbonic acid lithium salt (Li2CO3) excretion.[19][23] Two other infants had slight increases in thyrotropin (TSH) levels at 8 and 4 weeks of age, respectively, after Carbonic acid lithium salt (Li2CO3) exposure that began during pregnancy. Elevated TSH continued until maternal Carbonic acid lithium salt (Li2CO3) was stopped in one,[9] and normalized by 2 months postpartum in the other, despite continued exclusive breastfeeding.[20] Three mothers took Carbonic acid lithium salt (Li2CO3) carbonate during pregnancy and breastfeeding. The first infant was born to a mother who also took bupropion 300 mg and levothyroxine 50 to 75 mcg daily. She breastfed beyond 1 year of age. Her infant did not regain birth weight by 15 days of age, was somewhat hypotonic at 2 months of age, and was treated for gross and fine motor delay for the first year of life. The mother had a second infant on the same drug regimen. She exclusively breastfed her infant who developed normally without hypotonia. A second mother was taking a Carbonic acid lithium salt (Li2CO3) dosage of 900 mg daily. Her infant gained weight slowly, but weight gain increased with breastfeeding support and she exclusively breastfed her infant for 4 months. A third mother was taking 1350 mg of Carbonic acid lithium salt (Li2CO3) daily as well as escitalopram 10 mg, levothyroxine 25 mcg and heparin (dosage not stated) daily during pregnancy and breastfeeding. Her infant was normal and was exclusively breastfed until 8 weeks of age when the maternal serum Carbonic acid lithium salt (Li2CO3) concentration was excessive at 2.0 mEq/L. Breastfeeding was withheld for 2 days and the dosage lowered to 600 mg daily. She then breastfed successfully until 7 months of age.[7] A woman with bipolar disorder took prolonged-release Carbonic acid lithium salt (Li2CO3) carbonate 400 mg every 12 hours during pregnancy and postpartum. She breastfed her infant exclusively for 33 days, but introduced supplements for 16 days because of slow weight gain. After the 16 days, she exclusively breastfed her infant until 2.5 months of age, when mixed feeding was begun. The infant was monitored at 17 days, 1 month, 3.5 months and 5.5 months of age. No infant side effects were observed at any time. Carbonic acid lithium salt (Li2CO3) levels were not detectable, and serum creatinine and thyroid-stimulating hormone levels were normal.[22]

Carbonic acid lithium salt (Li2CO3) increases serum prolactin.[24][25][26] Galactorrhea was reported in a women taking Carbonic acid lithium salt (Li2CO3) carbonate for 50 days. Lactation ceased with Carbonic acid lithium salt (Li2CO3) discontinuation.[26] The prolactin level in a mother with established lactation may not affect her ability to breastfeed.