Question

I am a breastfeeding mother and i want to know if it is safe to use (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol? Is (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol safe for nursing mother and child? Does (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol extracts into breast milk? Does (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol has any long term or short term side effects on infants? Can (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol influence milk supply or can (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol decrease milk supply in lactating mothers?

(2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol lactation summary

(2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol is unsafe in breastfeeding
  • DrLact safety Score for (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol is 5 out of 8 which is considered Unsafe as per our analyses.
  • A safety Score of 5 indicates that usage of (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol may cause serious side effects in breastfed baby.
  • Our study of different scientific research indicates that (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol may cause moderate to high side effects or may affect milk supply in lactating mother.
  • Our suggestion is to use safer alternate options rather than using (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol .
  • It is recommended to evaluate the advantage of not breastfeeding while using (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol Vs not using (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol And continue breastfeeding.
  • While using (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol Its must to monitor child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol usage in lactation

No adverse effects have been reported, but check-up for the possibility of sedation, hypotension, hypoglycemia or bradycardia.

Answer by DrLact: About (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol usage in lactation

Because of its relatively extensive excretion into breastmilk and its renal excretion, other beta-adrenergic blocking drugs are preferred to (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol, especially while nursing a newborn or preterm infant.

(2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol Side Effects in Breastfeeding

Relevant published information on (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol was not found as of the revision date. A study of mothers taking beta-blockers during nursing found a numerically, but not statistically significant increased number of adverse reactions in those taking any beta-blocker. Although the ages of infants were matched to control infants, the ages of the affected infants were not stated. None of the mothers were taking (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol.[6]

(2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol Possible Effects in Breastfeeding

Relevant published information on the effects of beta-blockade or (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol during normal lactation was not found as of the revision date. A study in 6 patients with hyperprolactinemia and galactorrhea found no changes in serum prolactin levels following beta-adrenergic blockade with propranolol.[7]

Alternate Drugs

Bisoprolol(Low Risk)
Sotalol(Low Risk)
Atenolol(Unsafe)
Levobunolol(Low Risk)
Acebutolol(Unsafe)
Labetalol(Safe)
Carteolol(Unsafe)
Nebivolol(Unsafe)
Nadolol(Unsafe)
Carvedilol(Low Risk)
Timolol(Safe)
Diltiazem(Safe)
Sotalol(Low Risk)
Digoxin(Safe)
Quinidine(Safe)
Atenolol(Unsafe)
Propafenone(Low Risk)
Levobunolol(Low Risk)
Acebutolol(Unsafe)
Labetalol(Safe)
Verapamil(Safe)
Nadolol(Unsafe)
Amiodarone(Unsafe)
Lidocaine(Safe)
Timolol(Safe)
Bisoprolol(Low Risk)
Timolol(Safe)
Telmisartan(Unsafe)
Reserpine(Unsafe)
Diltiazem(Safe)
Bisoprolol(Low Risk)
Prazosin(Unsafe)
Ramipril(Low Risk)
Sotalol(Low Risk)
Losartan(Low Risk)
Lisinopril(Low Risk)
Chlorthalidone(Dangerous)
Irbesartan(Unsafe)
Isradipine(Low Risk)
Indapamide(Low Risk)
Captopril(Safe)
Atenolol(Unsafe)
Eprosartan(Low Risk)
Bumetanide(Low Risk)
Doxazosin(Safe)
Levobunolol(Low Risk)
Acebutolol(Unsafe)
Guanfacine(Low Risk)
Furosemide(Low Risk)
Bosentan(Low Risk)
Nisoldipine(Low Risk)
Fosinopril(Low Risk)
Labetalol(Safe)
Verapamil(Safe)
Nebivolol(Unsafe)
Amlodipine(Low Risk)
Felodipine(Low Risk)
Trandolapril(Dangerous)
Nadolol(Unsafe)
Torsemide(Low Risk)
Enalapril(Safe)
Carvedilol(Low Risk)
Valsartan(Low Risk)
Minoxidil(Safe)
Terazosin(Unsafe)
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.