Is Teicoplanin Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Teicoplanin? Is Teicoplanin safe for nursing mother and child? Does Teicoplanin extracts into breast milk? Does Teicoplanin has any long term or short term side effects on infants? Can Teicoplanin influence milk supply or can Teicoplanin decrease milk supply in lactating mothers?

Antibacterial glycopeptide, administered via intravenous or intramuscularinjection. Its pharmacokinetic data (high molecular weight, high percentage of plasma protein binding and no oral bioavailability) explain the negligible passage into milk observed (Fraissinet 2017) and the absence of side effects in a 52-day-old infant whose mother was being treated with teicoplanin (Kaplan 2017). Not being absorbed orally, there would be no passage to the infant's plasma from ingested breast milk. It is an antibiotic that is administered, if necessary, to newborns. The possible negativity of cultures in febrile infants whose mothers take antibiotics should be taken into account, as well as the possibility of gastroenteritis due to altered intestinal flora.

Teicoplanin is not approved for marketing in the United States by the U.S. Food and Drug Administration, but is available in other countries. Limited data indicate that teicoplanin is poorly excreted into breastmilk. Because teicoplanin is not orally absorbed it is unlikely to adversely affect the breastfed infant. One infant was safely breastfed during maternal therapy with teicoplanin and ceftriaxone. Until more information becomes available, monitor the breastfed infant for gastrointestinal disturbances such as diarrhea, particularly in newborn and preterm infants.

A mother who was exclusively nursing her 52-day-old infant developed a soft-tissue infection. She was treated with intravenous teicoplanin 400 mg every 12 hours for 3 doses, then 400 mg daily for 5 days total, intravenous ceftriaxone 1 gram daily, and topical mupirocin cream twice daily. A careful follow-up indicated that her infant had no adverse effects.[2]