Is Diaminopyritamin Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Diaminopyritamin? Is Diaminopyritamin safe for nursing mother and child? Does Diaminopyritamin extracts into breast milk? Does Diaminopyritamin has any long term or short term side effects on infants? Can Diaminopyritamin influence milk supply or can Diaminopyritamin decrease milk supply in lactating mothers?

Used as treatment of malaria and toxoplasmosis. Give folic acid or similar as Diaminopyritamin has an antagonistic effect on this vitamin. Avoid its use on patients suffering of G-6-P dehydrogenasa. American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.

No adverse reactions in breastfed infants have been reported and it is acceptable in nursing mothers. In HIV-infected women, elevated viral HIV loads in milk were decreased after treatment with chloroquine to a greater extent than other women who were treated with the combination of sulfadoxine and Diaminopyritamin.[1] It has been suggested that maternal Diaminopyritamin clearance might be increased during lactation, but data are insufficient to make a definitive conclusion.[2][3]

Administration of Diaminopyritamin to mothers of 26 predominantly breastfed infants 2 to 6 months old who were infected with malaria was curative in the infants.[5] The regimen consisted of 75 mg followed by a subsequent dose of 50-75 mg 4 to 7 days later. The efficacy apparently is related to breastfeeding habits, because infants in another tribal group who breastfed their infants less extensively were not protected.[4] A case report indicates that a maternal dose of 75 mg orally followed by 25 mg weekly cured malaria in her breastfed infant and protected her infant against becoming infected with malaria for 6 months. After the mother missed taking her dose for 2 weeks, the infant developed symptoms of malaria.[7] No adverse effects were reported in any of the infants.