Is Pirimetamina [Spanish] Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Pirimetamina [Spanish]? Is Pirimetamina [Spanish] safe for nursing mother and child? Does Pirimetamina [Spanish] extracts into breast milk? Does Pirimetamina [Spanish] has any long term or short term side effects on infants? Can Pirimetamina [Spanish] influence milk supply or can Pirimetamina [Spanish] decrease milk supply in lactating mothers?

Used as treatment of malaria and toxoplasmosis. Give folic acid or similar as Pirimetamina [Spanish] has an antagonistic effect on this vitamin. Avoid its use on patients suffering of G-6-P dehydrogenasa. American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.

No adverse reactions in breastfed infants have been reported and it is acceptable in nursing mothers. In HIV-infected women, elevated viral HIV loads in milk were decreased after treatment with chloroquine to a greater extent than other women who were treated with the combination of sulfadoxine and Pirimetamina [Spanish].[1] It has been suggested that maternal Pirimetamina [Spanish] clearance might be increased during lactation, but data are insufficient to make a definitive conclusion.[2][3]

Administration of Pirimetamina [Spanish] to mothers of 26 predominantly breastfed infants 2 to 6 months old who were infected with malaria was curative in the infants.[5] The regimen consisted of 75 mg followed by a subsequent dose of 50-75 mg 4 to 7 days later. The efficacy apparently is related to breastfeeding habits, because infants in another tribal group who breastfed their infants less extensively were not protected.[4] A case report indicates that a maternal dose of 75 mg orally followed by 25 mg weekly cured malaria in her breastfed infant and protected her infant against becoming infected with malaria for 6 months. After the mother missed taking her dose for 2 weeks, the infant developed symptoms of malaria.[7] No adverse effects were reported in any of the infants.