Question

I am a breastfeeding mother and i want to know if it is safe to use WR 2978? Is WR 2978 safe for nursing mother and child? Does WR 2978 extracts into breast milk? Does WR 2978 has any long term or short term side effects on infants? Can WR 2978 influence milk supply or can WR 2978 decrease milk supply in lactating mothers?

WR 2978 lactation summary

WR 2978 is safe in breastfeeding
  • DrLact safety Score for WR 2978 is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of WR 2978 is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that WR 2978 does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of WR 2978 safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About WR 2978 usage in lactation

Used as treatment of malaria and toxoplasmosis. Give folic acid or similar as WR 2978 has an antagonistic effect on this vitamin. Avoid its use on patients suffering of G-6-P dehydrogenasa. American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.

Answer by DrLact: About WR 2978 usage in lactation

No adverse reactions in breastfed infants have been reported and it is acceptable in nursing mothers. In HIV-infected women, elevated viral HIV loads in milk were decreased after treatment with chloroquine to a greater extent than other women who were treated with the combination of sulfadoxine and WR 2978.[1] It has been suggested that maternal WR 2978 clearance might be increased during lactation, but data are insufficient to make a definitive conclusion.[2][3]

WR 2978 Side Effects in Breastfeeding

Administration of WR 2978 to mothers of 26 predominantly breastfed infants 2 to 6 months old who were infected with malaria was curative in the infants.[5] The regimen consisted of 75 mg followed by a subsequent dose of 50-75 mg 4 to 7 days later. The efficacy apparently is related to breastfeeding habits, because infants in another tribal group who breastfed their infants less extensively were not protected.[4] A case report indicates that a maternal dose of 75 mg orally followed by 25 mg weekly cured malaria in her breastfed infant and protected her infant against becoming infected with malaria for 6 months. After the mother missed taking her dose for 2 weeks, the infant developed symptoms of malaria.[7] No adverse effects were reported in any of the infants.

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Doxycycline(Low Risk)
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Naftifine(Safe)
Moxifloxacin(Low Risk)
Primaquine(Low Risk)
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Malathion(Low Risk)
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Cefdinir(Safe)
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Didanosine(Unsafe)
Lindane(Unsafe)
Saquinavir(Unsafe)
Dapsone(Low Risk)
Primaquine(Low Risk)
Atovaquone(Low Risk)
Quinine(Safe)
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Pyrantel(Safe)
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Lindane(Unsafe)
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Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. We do not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.