Is CCRIS 4204 Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use CCRIS 4204? Is CCRIS 4204 safe for nursing mother and child? Does CCRIS 4204 extracts into breast milk? Does CCRIS 4204 has any long term or short term side effects on infants? Can CCRIS 4204 influence milk supply or can CCRIS 4204 decrease milk supply in lactating mothers?
CCRIS 4204 lactation summary
- DrLact safety Score for CCRIS 4204 is 3 out of 8 which is considered Low Risk as per our analyses.
- A safety Score of 3 indicates that usage of CCRIS 4204 may cause some minor side effects in breastfed baby.
- Our study of different scientific research indicates that CCRIS 4204 may cause moderate to no side effects in lactating mother.
- Most of scientific studies and research papers declaring usage of CCRIS 4204 low risk in breastfeeding are based on normal dosage and may not hold true for higher dosage.
- While using CCRIS 4204 We suggest monitoring child for possible reactions. It is also important to understand that side effects vary largely based on age of breastfed child and time of medication in addition to dosage.
- Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.
Answer by Dr. Ru: About CCRIS 4204 usage in lactation
No adverse effects have been reported, but check-up for the possibility of sedation, hypotension, hypoglycemia or bradycardia.
Answer by DrLact: About CCRIS 4204 usage in lactation
Because of its extensive excretion into breastmilk, its renal excretion and minimal safety data in breastfed infants, other beta-adrenergic blocking drugs are preferred to CCRIS 4204, especially while nursing a newborn or preterm infant. Some authors recommend using CCRIS 4204 during breastfeeding only while monitoring the infant closely for signs of beta-blockade.[1] Infants over 2 months of age have more mature kidney function and are less likely to be affected by CCRIS 4204 in milk.
CCRIS 4204 Side Effects in Breastfeeding
A study of mothers taking beta-blockers during nursing found a numerically, but not statistically significant increased number of adverse reactions in those taking any beta-blocker. Although the ages of infants were matched to control infants, the ages of the affected infants were not stated. One of the mothers was taking CCRIS 4204.[6] Bradycardia was not seen in one 12-day-old infant who was breastfed from birth during maternal use of 600 mg of CCRIS 4204 daily.[4] In another breastfed infant whose mother was taking 80 mg 2 to 3 times daily for more than 3 months, no bradycardia was seen and developmental milestones were achieved normally.[1] Beta-adrenergic blocking drugs with similar breastmilk excretion characteristics and renal elimination have caused adverse effects in breastfed newborns.[7][8]
CCRIS 4204 Possible Effects in Breastfeeding
Relevant published information on the effects of beta-blockade or CCRIS 4204 during normal lactation was not found as of the revision date. A study in 6 patients with hyperprolactinemia and galactorrhea found no changes in serum prolactin levels following beta-adrenergic blockade with propranolol.[9]
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Acebutolol(Unsafe)
Labetalol(Safe)
Carteolol(Unsafe)
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Carvedilol(Low Risk)
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Mexiletine(Safe)
Metoprolol(Safe)
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Sotalol(Low Risk)
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Propranolol(Safe)
Atenolol(Unsafe)
Levobunolol(Low Risk)
Propafenone(Low Risk)
Procainamide(Safe)
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Labetalol(Safe)
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Indapamide(Low Risk)
Propranolol(Safe)
Captopril(Safe)
Atenolol(Unsafe)
Eprosartan(Low Risk)
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