Is Avelumab Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Avelumab? Is Avelumab safe for nursing mother and child? Does Avelumab extracts into breast milk? Does Avelumab has any long term or short term side effects on infants? Can Avelumab influence milk supply or can Avelumab decrease milk supply in lactating mothers?

No information is available on the clinical use of avelumab during breastfeeding. Because avelumab is a large protein molecule with a molecular weight of about 147,000, the amount in milk is likely to be very low and absorption is unlikely because it is probably destroyed in the infant's gastrointestinal tract. Until more data become available, avelumab should be used with caution during breastfeeding, especially while nursing a newborn or preterm infant. The manufacturer recommends that mothers not breastfeed during treatment and for at least one month after the last dose of avelumab. Avelumab is a human immunoglobulin G1 (IgG1) lambda antibody. Holder pasteurization (62.5 degrees C for 30 minutes) decreases the concentration of endogenous immunoglobulin G by up to 79%.[1][2] A study of 67 colostrum samples that underwent Holder pasteurization found that IgG amounts decreased by 34 to 40%. Specific IgG subclasses decreased by different amounts, with IgG1 activity decreasing by about 37%.[3] None of the studies measured IgG activity.