Is UNII-6S082C9NDT Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use UNII-6S082C9NDT? Is UNII-6S082C9NDT safe for nursing mother and child? Does UNII-6S082C9NDT extracts into breast milk? Does UNII-6S082C9NDT has any long term or short term side effects on infants? Can UNII-6S082C9NDT influence milk supply or can UNII-6S082C9NDT decrease milk supply in lactating mothers?

We are working on a comment for this product.

If UNII-6S082C9NDT is required by the mother, it is not a reason to discontinue breastfeeding. Because of the lack of data on use during breastfeeding, other antidepressants are preferred during breastfeeding, especially while nursing a newborn or preterm infant.

Published information on UNII-6S082C9NDT was not found as of the revision date. Follow-up for 1 to 3 years in a group of 20 breastfed infants whose mothers were taking a tricyclic antidepressant found no adverse effects on growth and development.[1] Two small controlled studies indicate that other tricyclic antidepressants have no adverse effect on infant development.[2][3] In another study, 25 infants whose mothers took a tricyclic antidepressant during pregnancy and lactation were tested formally between 15 to 71 months and found to have normal growth and development.[4] However, none of the mothers in any of these studies took UNII-6S082C9NDT.

UNII-6S082C9NDT increases serum prolactin levels[5] and has caused at least one case of galactorrhea.[6] The maternal prolactin level in a mother with established lactation may not affect her ability to breastfeed. An observational study looked at outcomes of 2859 women who took an antidepressant during the 2 years prior to pregnancy. Compared to women who did not take an antidepressant during pregnancy, mothers who took an antidepressant during all 3 trimesters of pregnancy were 37% less likely to be breastfeeding upon hospital discharge. Mothers who took an antidepressant only during the third trimester were 75% less likely to be breastfeeding at discharge. Those who took an antidepressant only during the first and second trimesters did not have a reduced likelihood of breastfeeding at discharge.[7] The antidepressants used by the mothers were not specified. A retrospective cohort study of hospital electronic medical records from 2001 to 2008 compared women who had been dispensed an antidepressant during late gestation (n = 575) to those who had a psychiatric illness but did not receive an antidepressant (n = 1552) and mothers who did not have a psychiatric diagnosis (n = 30,535). Women who received an antidepressant were 37% less likely to be breastfeeding at discharge than women without a psychiatric diagnosis, but no less likely to be breastfeeding than untreated mothers with a psychiatric diagnosis.[8] None of the mothers were taking UNII-6S082C9NDT.