Is Enasidenib Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Enasidenib? Is Enasidenib safe for nursing mother and child? Does Enasidenib extracts into breast milk? Does Enasidenib has any long term or short term side effects on infants? Can Enasidenib influence milk supply or can Enasidenib decrease milk supply in lactating mothers?
Answer by DrLact: About Enasidenib usage in lactation
No information is available on the clinical use of enasidenib during breastfeeding. Because enasidenib is 98.5% bound to plasma proteins and its active metabolite is 96.6% bound to plasma proteins, the amount in milk is likely to be low. However, the half-life of enasidenib is 137 hours and it might accumulate in the infant. The manufacturer recommends that breastfeeding be discontinued during enasidenib therapy and for at least 1 month after the end of therapy.
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