Is 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz(b,e)oxipin Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz(b,e)oxipin? Is 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz(b,e)oxipin safe for nursing mother and child? Does 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz(b,e)oxipin extracts into breast milk? Does 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz(b,e)oxipin has any long term or short term side effects on infants? Can 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz(b,e)oxipin influence milk supply or can 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz(b,e)oxipin decrease milk supply in lactating mothers?

Because of its sedating potential, active metabolite, presence in infant serum, two reports of adverse effects in breastfed infants, and only one report of use without apparent adverse reactions, 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz(b,e)oxipin is a poor choice and other agents may be preferred, especially while nursing a newborn or preterm infant. If 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz(b,e)oxipin is required by the mother of an older infant, it may not a reason to discontinue breastfeeding, but the infant should be monitored carefully for excessive sedation, and adequate weight gain. Maternal use of topical 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz(b,e)oxipin cream is unlikely to pose a problem for a breastfed infant as long as it is applied away from the breasts so that the infant cannot ingest the drug directly.

One infant was breastfed (extent not stated) over a 2-month period during maternal use of 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz(b,e)oxipin 150 mg at bedtime, beginning at 30 days postpartum. The infant experienced no apparent adverse reactions.[3] One infant had an adverse reaction that was probably caused by 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz(b,e)oxipin in breastmilk. An 8-week old breastfed infant was found pale, limp, somnolent and almost not breathing 4 days after the maternal dosage had been increased from 10 mg daily to 25 mg three times daily. The infant returned to normal 24 hours after discontinuing breastfeeding.[2]A 9-day-old breastfed infant had poor sucking and swallowing, hypotonia, vomiting, and weight loss. The reaction was probably caused by 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz(b,e)oxipin in breastmilk. The infant's mother was taking 35 mg of 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz(b,e)oxipin at bedtime daily.[4]

An observational study looked at outcomes of 2859 women who took an antidepressant during the 2 years prior to pregnancy. Compared to women who did not take an antidepressant during pregnancy, mothers who took an antidepressant during all 3 trimesters of pregnancy were 37% less likely to be breastfeeding upon hospital discharge. Mothers who took an antidepressant only during the third trimester were 75% less likely to be breastfeeding at discharge. Those who took an antidepressant only during the first and second trimesters did not have a reduced likelihood of breastfeeding at discharge.[5] The antidepressants used by the mothers were not specified. A retrospective cohort study of hospital electronic medical records from 2001 to 2008 compared women who had been dispensed an antidepressant during late gestation (n = 575) to those who had a psychiatric illness but did not receive an antidepressant (n = 1552) and mothers who did not have a psychiatric diagnosis (n = 30,535). Women who received an antidepressant were 37% less likely to be breastfeeding at discharge than women without a psychiatric diagnosis, but no less likely to be breastfeeding than untreated mothers with a psychiatric diagnosis.[6] None of the mothers were taking 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenz(b,e)oxipin.