Question

I am a breastfeeding mother and i want to know if it is safe to use 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine? Is 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine safe for nursing mother and child? Does 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine extracts into breast milk? Does 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine has any long term or short term side effects on infants? Can 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine influence milk supply or can 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine decrease milk supply in lactating mothers?

2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine lactation summary

2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine is safe in breastfeeding
  • DrLact safety Score for 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine is 1 out of 8 which is considered Safe as per our analyses.
  • A safety Score of 1 indicates that usage of 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine is mostly safe during lactation for breastfed baby.
  • Our study of different scientific research also indicates that 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine does not cause any serious side effects in breastfeeding mothers.
  • Most of scientific studies and research papers declaring usage of 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine safe in breastfeeding are based on normal dosage and may not hold true for higher dosage.
  • Score calculated using the DrLact safety Version 1.2 model, this score ranges from 0 to 8 and measures overall safety of drug in lactation. Scores are primarily calculated using publicly available case studies, research papers, other scientific journals and publically available data.

Answer by Dr. Ru: About 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine usage in lactation

Small amount is excreted into breast milk. No adverse effect has been observed in infants. Galactorrhea and oligomenorrhea have been reported in women.

Answer by DrLact: About 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine usage in lactation

Because no information is available on the use of 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine during breastfeeding, another drug may be preferred, especially while nursing a newborn or preterm infant. If 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine is required by the mother, it is not a reason to discontinue breastfeeding. Exclusively breastfed infants should be monitored if this drug is used during lactation, possibly including measurement of serum levels to rule out toxicity if there is a concern.

2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine Possible Effects in Breastfeeding

Two cases of galactorrhea have been reported in nonbreastfeeding women who were taking 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine.[1][2] The clinical relevance of these findings in nursing mothers is not known. The prolactin level in a mother with established lactation may not affect her ability to breastfeed. An observational study looked at outcomes of 2859 women who took an antidepressant during the 2 years prior to pregnancy. Compared to women who did not take an antidepressant during pregnancy, mothers who took an antidepressant during all 3 trimesters of pregnancy were 37% less likely to be breastfeeding upon hospital discharge. Mothers who took an antidepressant only during the third trimester were 75% less likely to be breastfeeding at discharge. Those who took an antidepressant only during the first and second trimesters did not have a reduced likelihood of breastfeeding at discharge.[3] The antidepressants used by the mothers were not specified. A retrospective cohort study of hospital electronic medical records from 2001 to 2008 compared women who had been dispensed an antidepressant during late gestation (n = 575) to those who had a psychiatric illness but did not receive an antidepressant (n = 1552) and mothers who did not have a psychiatric diagnosis (n = 30,535). Women who received an antidepressant were 37% less likely to be breastfeeding at discharge than women without a psychiatric diagnosis, but no less likely to be breastfeeding than untreated mothers with a psychiatric diagnosis.[4] None of the mothers were taking 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine.
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