Is Desmethylloxapin Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Desmethylloxapin? Is Desmethylloxapin safe for nursing mother and child? Does Desmethylloxapin extracts into breast milk? Does Desmethylloxapin has any long term or short term side effects on infants? Can Desmethylloxapin influence milk supply or can Desmethylloxapin decrease milk supply in lactating mothers?

Small amount is excreted into breast milk. No adverse effect has been observed in infants. Galactorrhea and oligomenorrhea have been reported in women.

Because no information is available on the use of Desmethylloxapin during breastfeeding, another drug may be preferred, especially while nursing a newborn or preterm infant. If Desmethylloxapin is required by the mother, it is not a reason to discontinue breastfeeding. Exclusively breastfed infants should be monitored if this drug is used during lactation, possibly including measurement of serum levels to rule out toxicity if there is a concern.

Two cases of galactorrhea have been reported in nonbreastfeeding women who were taking Desmethylloxapin.[1][2] The clinical relevance of these findings in nursing mothers is not known. The prolactin level in a mother with established lactation may not affect her ability to breastfeed. An observational study looked at outcomes of 2859 women who took an antidepressant during the 2 years prior to pregnancy. Compared to women who did not take an antidepressant during pregnancy, mothers who took an antidepressant during all 3 trimesters of pregnancy were 37% less likely to be breastfeeding upon hospital discharge. Mothers who took an antidepressant only during the third trimester were 75% less likely to be breastfeeding at discharge. Those who took an antidepressant only during the first and second trimesters did not have a reduced likelihood of breastfeeding at discharge.[3] The antidepressants used by the mothers were not specified. A retrospective cohort study of hospital electronic medical records from 2001 to 2008 compared women who had been dispensed an antidepressant during late gestation (n = 575) to those who had a psychiatric illness but did not receive an antidepressant (n = 1552) and mothers who did not have a psychiatric diagnosis (n = 30,535). Women who received an antidepressant were 37% less likely to be breastfeeding at discharge than women without a psychiatric diagnosis, but no less likely to be breastfeeding than untreated mothers with a psychiatric diagnosis.[4] None of the mothers were taking Desmethylloxapin.