I am a breastfeeding mother and i want to know if it is safe to use Acalabrutinib? Is Acalabrutinib safe for nursing mother and child? Does Acalabrutinib extracts into breast milk? Does Acalabrutinib has any long term or short term side effects on infants? Can Acalabrutinib influence milk supply or can Acalabrutinib decrease milk supply in lactating mothers?
No information is available on the clinical use of acalabrutinib during breastfeeding. Because acalabrutinib is over 97% bound to plasma proteins, and the half-life of the drug and metabolite are less than 7 hours, the amount in milk is likely to be low. However, the protein binding of the active metabolite is not known and the manufacturer recommends that breastfeeding be discontinued during acalabrutinib therapy and for at least 2 weeks after the final dose.