Is Ganciclovir Safe in Breastfeeding

I am a breastfeeding mother and i want to know if it is safe to use Ganciclovir? Is Ganciclovir safe for nursing mother and child? Does Ganciclovir extracts into breast milk? Does Ganciclovir has any long term or short term side effects on infants? Can Ganciclovir influence milk supply or can Ganciclovir decrease milk supply in lactating mothers?

Synthetic nucleoside which is analogue of guanine, structurally very closed related to acyclovir.Indicated for the treatment and prevention of Cytomegalovirus (CMV) in immunocompromised patients. At latest update no published data on excretion into breast milk were found. It is used in newborns and premature who are affected with CMV infection.Its low oral bioavailability hinders the passage from ingested milk towards the infant’s plasma, except in preterm babies and immediate neonatal period, which may show an increased intestinal permeability.

Several factors might affect the decision to use ganciclovir in a nursing mother. No information is available on the clinical use of ganciclovir during breastfeeding. Cytomegalovirus (CMV) can be transmitted to infants though breastmilk, with preterm and immunocompromised infants at greatest risk. No information is available on any changes in the risk of transmission if the mother is being treated with ganciclovir. Although the manufacturer recommends avoiding breastfeeding during ganciclovir use because of the risk of infant drug toxicity, neonates with CMV infections are often treated directly with ganciclovir. If the mother has a concurrent infection with HIV, breastfeeding is not recommended in the United States and other developed countries.