Is Bendamustine Safe in Breastfeeding
Question
I am a breastfeeding mother and i want to know if it is safe to use Bendamustine? Is Bendamustine safe for nursing mother and child? Does Bendamustine extracts into breast milk? Does Bendamustine has any long term or short term side effects on infants? Can Bendamustine influence milk supply or can Bendamustine decrease milk supply in lactating mothers?
Answer by DrLact: About Bendamustine usage in lactation
No information is available on the use of bendamustine during breastfeeding. Most sources consider breastfeeding to be contraindicated during maternal antineoplastic drug therapy, especially alkylating agents such as bendamustine.[1] The manufacturer recommends that breastfeeding be discontinued during bendamustine therapy. Based on the half-life of the drug and its metabolites, the drug should be eliminated from the milk by 24-48 hours after the last dose.
Bendamustine Possible Effects in Breastfeeding
Some evidence indicates that carmustine can increase serum prolactin.[2]